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Pathology MCQ

Pathology MCQ. PHASE 1. 1.Which of the following appear in the red cells of Ivemark syndrome/ asplenic individuals? Macroovalocytosis Basophilic stippling Howell-Jolly bodies Target cells. 2. The life span of platelets in circulation is about? a. 1 to 3 days b.3 to 5 days

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Pathology MCQ

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  1. Pathology MCQ PHASE 1

  2. 1.Which of the following appear in the red cells of Ivemark syndrome/asplenic individuals? • Macroovalocytosis • Basophilic stippling • Howell-Jolly bodies • Target cells

  3. 2. The life span of platelets in circulation is about? a. 1 to 3 days b.3 to 5 days c. 5 to 7 days d. 7 to 10 days

  4. 3. A 13 yr old child suffered from dysentery one week ago, currently complaining of hematuria and raised serum creatinine. PBS examination is expected to show: • Target cell • Spherocyte • Schistocyte • Bite cell

  5. 4. HbC is best illustrated as? • Α2ß23Glu→Lys • Α2ß24Glu→Lys • Α2ß25Glu→Lys • Α2ß26Glu→Lys

  6. 5. The 4T ‘s scoring system for pre-test probability of HIT includes all except: a. Thrombocytopenia b. Timing of platelet count fall c. Thrombosis d. Treatment dose

  7. 6.In comparison to myeloma,which is more frequent in plasma cell leukemia: • Osteolytic lesion • Bone pain • Renal failure • All of the above

  8. 7. Leukaemia with t(15;17)(q22;q12) usually has the immunophenotype: • CD13,CD33,CD15,CD117 • CD13,CD33,CD117,HLADR • CD13,CD33,CD117,cMPO • CD13,CD33,CD15,cMPO

  9. 8. Match the following with respect to iron deficiency anaemia: • Red cell zinc protoporphyrin (ZPP) • Serum transferrin receptor • Transferrin saturation • Hepcidin • Increases 2. Decreases 3. Increases 4. Decreases

  10. 9. Which of the following is safe in therapeutic doses in patients with G6PD deficiency: • Primaquine • Acetaminophen • Sulfamethoxazole • Dapsone

  11. 10. The affinity of haemoglobin for Oxygen is decreased by all except: • Fever • Alkalosis • Binding of CO2 • Binding of 2,3-DPG

  12. 11. An Increased percentage of HbA2 is expected in : a. αthal trait b. ßthal trait c. δßthal trait d. All of the above

  13. 12. A 15 yr old child presents with fever and generalised petechiae, lab investigation reveal: • Hb 6gm% MCV = 105fl MCH = 30pg • WBC = 1.2 X 109 /L PC = 10 X 109 /L • LYMP%- 73%, GRAN%-25%,MID%-2% • BM: Hypo cellular. What is the most likely diagnosis? • Severe aplasticanemia • Very severe aplasticanemia • Nonsevereaplasticanemia • Hypoplastic MDS

  14. 13. All are direct thrombin inhibitors except: • Fondaparinux sodium • Bivalirudin • Argatroban • Lepirudin

  15. 14. For the given coagulation work up results which is the most probable diagnosis: • BT- 5 min • PT- 11 sec ( 10 sec) • APTT- 50sec (32 sec) • Mixing study with factor IX deficient plasma: APTT – 40 sec • Hemophilia A • Hemophilia B • Hemophilia C • Factor VIII inhibitor positive

  16. 15. Regarding febrile nonhemolytic transfusion reaction false is: • More common in multiply transfused patients • HLA antibodies are most common • Leucodepletion of blood products is not helpful • Due to transfusion of cytokines

  17. 16. Which is not a GpIIb/IIIa inhibitor: • Abciximab • Eptifibatide • Tirofiban • Argatroban

  18. 17.Haemolytic disease of new born(erythroblastosisfetalis ) is an example of: • Type I hypersenstivity • Type II hypersenstivity • Type III hypersenstivity • Type IV hypersenstivity

  19. 18. Pre-transfusion cross-match is not required for: • Cryoprecipitate • pRBC • FFP • Granulocyte tranfusion

  20. 19. Neutrophilia is seen in all except: • Leucocyte adhesion defect • Steroid administration • Lithium therapy • Kostmann syndrome

  21. 20. Infectious complications of blood transfusion may result from all except: • HTLV I • HTLV II • West Nile virus • None of the above

  22. 21. Good prognosis ALL: • t(4;11) • t(9;22) • t(12;21) • t(1;19)

  23. 22. For diagnosis of Smoldering Myeloma, false is: • BM plasma cells ≤ 10% • Absence of anemia • Serum monoclonal protein ≥ 3g/dl • None of the above

  24. 23. IPSS for MDS includes all except: • Marrow blast % • Karyotype • Cytopenias • Age

  25. 24. Hairy cell leukaemia , immunophenotype: • Bright CD20,CD10,CD25,CD103 • Dim CD20,CD10,CD25,CD103 • Bright CD20,CD11c,CD25,CD103 • Dim CD20,CD11c,CD25,CD103

  26. 25. WHO definition of anaemia in pregnancy requires Hb below: • 10g% • 11g% • 12g% • 13g%

  27. 26. Albino child with repeated infection most probable diagnosis: • Grescilli syndrome • Chediac Higashi syndrome • Dohle bodies • Toxic granules

  28. 27. Comment on PBS:

  29. 28. Identify the cell with arrow head: Gaucher cell Mott cell Histoplasma inclusion Fungal bodies

  30. 29. Identify the abnormality in the Karyotype

  31. 30.Identify the cytogenetic finding shown in the FISH metaphase spread.

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