1 / 13

Mechanism of Insulin Secretion by  -cells

Mechanism of Insulin Secretion by  -cells. ROLE OF THE K ATP CHANNEL. NO K ATP CHANNEL ACTIVITY, MEMBRANE DEPOLARIZATION AND HIGHER [Ca 2+ ]i IN PANCREATIC Kir6.2 -/- β-CELLS. GLUCOSE AND TOLBUTAMIDE NO LONGER STIMUALTE INCREASES IN [Ca 2+ ]i IN Kir6.2 -/- β-CELLS.

muriel
Download Presentation

Mechanism of Insulin Secretion by  -cells

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Mechanism of Insulin Secretion by -cells ROLE OF THE KATP CHANNEL

  2. NO KATP CHANNEL ACTIVITY, MEMBRANE DEPOLARIZATION AND HIGHER [Ca2+]i IN PANCREATIC Kir6.2-/- β-CELLS

  3. GLUCOSE AND TOLBUTAMIDE NO LONGER STIMUALTE INCREASES IN [Ca2+]i IN Kir6.2-/- β-CELLS

  4. GLUCOSE NO LONGER STIMULATE INSULIN SECRETION IN Kir6.2-/- β-CELLS

  5. NEAR NORMAL GLUCOSE TOLERANCE AND INCREASED INSULIN SENSITIVITY IN Kir6.2-/- MICE

  6. INFILTRATION OF α-CELLS IN THE MIDDLE OF THE Kir6.2-/- PANCREATIC ISLETS

More Related