Exploring Biophysics: From DNA to Organism Behavior

1. Overview of research in Biophysics Institute @NCU. 中央大學生物物理所 From DNA to collective behavior of organisms http://www.phy.ncu.edu.tw/ibp/

2. Institute of BioPhysicsat NCU 中央大學生物物理所 Biophysics Life Science 生命科學系 Inst. Systems Biology & Bioinformatics 系統生物所 Brain Research Center,UST 聯合大學腦科學中心 Institute of Phys., Academia Sinica 中研院物理所 Soft Condensed Matter Physics Dept. Center for Complex Systems 複雜系統中心

3. Why BioPhysics ? • Material Nature of Bio-substances affect Biological properties. (Evolution made use of the physical properties of bio-materials) • Physical principles & Laws holds from microscopic level  macroscopic level • Traditional Biology is descriptive, non-quantitative

4. Why BioPhysics ? • Physics is universal. • Rise of molecular biology: DNA, RNA, protein are universal in all living matters • Universality in Central Dogma: DNARNAproteinBiological functions… • New, interesting, exciting & useful. • Lots of unsolved important problems. • Techniques & Methodology in physics can probe the fundamental principles in bio-systems of a wide spectrum of scales in a quantitative way.

5. 國立中央大學 生物物理研究所 • Officially established in 2004 • 教授: 6 副教授: 1 助理教授 3 • 合聘教授: 2 合聘助理教授: 1 • 現有從事生物物理領域在學研究生 碩士班：23 博士班：8 • 博士後: 3 • 以物理之技術或方法去探討生物系統中存在之基本原理，從而對生物過程提供深入及定量之了解。 • 「5年500億」頂尖中心經費建立生物物理共用核心設施 • 歡迎物理與非物理背景同學加入.中大及中研院提供獎學金

6. BioPhysics Institute @NCU • Officially established in 2004 • Professors: 6 Assoc. Prof.: 1 Assist. Prof. 3 • Adj. Prof.: 2 Adj. assist.prof.: 1 • Graduate students working on areas in biophysics M.S.：23 Ph. D.：8 • Postdocs: 5 • aims at achieving some quantitative description of biological processes and search for the fundamental principles buried in these highly complex biological phenomena • 「5 years 500B」grant to support research & building of core facility labs. • Cross-disciplinary: researchers/students from physics & non-physics background

8. Wide Spectrum • Length Scales: nm  mm  mm  cm  m  km DNA,RNA,protein, intracellular, virus, bacteria, Intercellular, collective motion, insects, animanls/plants, migration • Time Scales: fs  ps  ms  ms  s e transfer,H-bonding,water DNA,RNA,protein rearrangement , protein folding DNA transcription  hr  day  year  Byr cell division Earth organisms , animal migration evolution • Knowledge: Interdisciplinary 跨越各學科領域 MathematicsPhysicsChemistryBiologyMedical • Biophysicist is a TRUE Scientist ! • 需要物理與非物理背景人材加入!

9. BioPhysics Theory Groups at NCU Soft matters • 陳培亮Peilong Chen: bio-hydrodynamics, mechanics of propulsion in living organisms,pattern formation in biology • 陳宣毅Hsuen-Yi Chen:complex fluids, cell adhesion, collective motion in flocks • 黎璧賢Pik-Yin Lai:DNA physics, biomolecular chain models, neurons, biological networks • 李紀倫Chi-Lun Lee:protein folding, charged biomolecules • 梁鈞泰Kwan-tai Leung: self-propelling motion in organisms, flocking, non-equilibrium bio-processes • 高仲明Chung-ming Ko:Evolution models, astrobiology • 王敏生Min-Sheng Wang:Neural Networks, brain wave & MEG analysis • 李弘謙Hoong-Chien Lee:Bioinformatics, protein physics, genome/DNA sequence analysis Biophysics

10. BioPhysics Experimental Labs at NCU • Bio-Soft Core Facilities Lab. : BioAFM, Confocal microscopy, Wet Labs, Bio samples, fast imaging systems, fluorescence microscopy… • Complex System Lab.伊林Lin I:micro-motion of bio- and soft materials in confined spots, dynamics of neuronal system, laser pulse-soft matter interaction • Biophysics Lab.陳方玉Fang Yu Chen:Biomembrane, Membrane-active Peptides, Effect of peptide-forming pore on neuron function • Bio-membrane Lab.薛雅薇Ya-Wei Hsueh:lipid rafts in cell membranes, NMR spectroscopy, AFM measurement • Bio-Soft Matters Lab.黎璧賢 Pik-Yin Lai, 陳志強 C.K. Chan & 林耿慧K.H.Lin: • interactions in cells, neuronal networks, DNA mechanics & hydrodynamics, biomaterials • Soft-condensed Matter Lab.陳培亮Peilong Chen: bio-hydrodynamics, mechanics of propulsion in living organisms

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