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TABLETS

TABLETS. a mixture of powders compacted to form a single, rigid body most common dosage form possess a number of advantages. Types. intended for release into GIT compressed tablets multiple compressed tablets effervescents chewable buccal or sublingual vaginal coated tablets

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TABLETS

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  1. TABLETS • a mixture of powders compacted to form a single, rigid body • most common dosage form • possess a number of advantages CHEE 440

  2. Types • intended for release into GIT • compressed tablets • multiple compressed tablets • effervescents • chewable • buccal or sublingual • vaginal • coated tablets • polymer film, gelatin • extended release • immediate release CHEE 440

  3. Desired Properties • contains stated amount of drug • able to withstand stresses of manufacture, transport and handling • provides desired bioavailability • acceptable to patient CHEE 440

  4. Drug Release CHEE 440

  5. Tabletting Process • Basics • powders fed into a die • powder compressed between punches • tablet ejected from die CHEE 440

  6. Machinery rotary tablet press CHEE 440

  7. Tablet Components • drug (5-10%) • fillers (80%) • binders • disintegrants • antifrictional agents • antiadherents, glidants, lubricants • miscellaneous CHEE 440

  8. Tabletting • Powder Properties • free flowing particles • cohesion of particles upon compaction • compacted particles must not adhere to punches and die • 3 tabletting methods • wet granulation • dry granulation • direct compression CHEE 440

  9. Powder flow • important to obtain uniform flow • affected by particle properties • adhesion • cohesion • size • shape • density CHEE 440

  10. Powders • packing geometry • shifting under vibration • affected by size and size distribution CHEE 440

  11. Powders • flow affected by hopper design • How to improve hopper flow? CHEE 440

  12. Wet Granulation CHEE 440

  13. Dry Granulation CHEE 440

  14. Direct Compression CHEE 440

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