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UMAR A. JENIE Indonesian Institute of Sciences (LIPI); Department of Medicinal Chemistry,

BIOMIMETICS CHEMISTRY New Field in Chemistry Emerging from the Advancement of Biotechnology Workshop on The Establishment of BINASIA Indonesia Nodal 27-28 July 2005, Jakarta, Indonesia. UMAR A. JENIE Indonesian Institute of Sciences (LIPI); Department of Medicinal Chemistry,

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UMAR A. JENIE Indonesian Institute of Sciences (LIPI); Department of Medicinal Chemistry,

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  1. BIOMIMETICS CHEMISTRYNew Field in ChemistryEmerging from the Advancement of BiotechnologyWorkshop onThe Establishment of BINASIA Indonesia Nodal27-28 July 2005, Jakarta, Indonesia UMAR A. JENIE Indonesian Institute of Sciences (LIPI); Department of Medicinal Chemistry, Faculty of Pharmacy, Gadjah Mada University (UGM)

  2. BIOMIMETICS CHEMISTRY • Biomimetics chemistry is not Biotechnolgy, it is a new field in Chemical Sciences concerns with synthesizing product/s that could imitate (mimics) biological function and processes. • Development of biomimetics chemistry depends mainly in the advancement of molecular based biotechnology which elucidating biosynthetic mechanism of bio-products.

  3. Molecular Biology Mechanisms of Biological activities and Biosynthesis mechanisms Biomimetic Chemistry Biomimetic Products & Processes

  4. BIOMIMETICS CHEMISTRY is a branch of chemistry that study on how to make products: • Biomimetic Products (making products having function similar or identical to that of the biological products) • Biomimetic Processes (organic synthesis based on biosynthetic mechanisms)

  5. BIOMIMETIC PRODUCTS • ARTIFICIAL BIOPRODUCTS Example: Artificial Hb Organic chemists have been trying to construct and develop organic molecule that have capability to cacth up reversibly oxygen from the air, similar to that of the haemoglobine. This molecule called: PICKET FENCE PORPHYRINS.

  6. Haem binds oxygen reversibly

  7. BIOMIMETIC PRODUCT:PICKET FENCE PORPHYRINS

  8. Oxygen will be trapped by thePorphyrins

  9. BIOMIMETIC PROCESS • BIOSYNTHESIS PATHWAY Organic chemists have been inspired by biosynthesis pathways of secondary metabolites occurred in nature. They are using such natural mechanism to construct natural products. Such approach known as Biomimetic Synthesis.

  10. BIOMIMETIC PROCESSbased on Biosynthetic Mechanism • LANOSTEROL BIOSYNTHESIS lanosterol biosynthesis proceeds via Mevalonic Pathway, in which the intermediate squalene-2,3-epoxide undergoes protonation, followed by MW rearrangement to produce lanosterol.

  11. LANOSTEROL BIOSYNTHESIS

  12. LANOSTEROL BIOSYNTHESIS Lanosterol

  13. Johnson constructed the triene compound to mimic the natural squalene

  14. Johnson’s Biomimetic Synthesis ofProgesteron

  15. FUTURE DEVELOPMENT • Biomimetic techniques could be used for synthesis of a complex biological molecules, such as steroids, with shorter step of reactions than the conventional ones. • Biomimetic techniques could also overcome stereochemical problems faced by conventional synthesis

  16. THANK YOU

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