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Neuro Infections + sequalae

Neuro Infections + sequalae. Quiz. What are the most common organisms implicated in bacterial meningitis in children?. What are the most common organisms implicated in bacterial meningitis in children?. a) N. meningitidis, H. influenzae b) S. pneumoniae, L. monocytogenes

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Neuro Infections + sequalae

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  1. Neuro Infections + sequalae Quiz

  2. What are the most common organisms implicated in bacterial meningitis in children?

  3. What are the most common organisms implicated in bacterial meningitis in children? a) N. meningitidis, H. influenzae b) S. pneumoniae, L. monocytogenes c) E. coli, group B streptococci d) N. meningitidis, S. pneumoniae

  4. What CSF findings would be most suggestive of bacterial meningitis?

  5. What CSF findings would be most suggestive of bacterial meningitis? • Low turbidity, positive latex agglutination test, CSF/ serum glucose ratio = 0.5 • PMN leukocytosis (400/mm3), CSF/ serum glucose ratio = 0.3, increased protein, negative culture • CSF opening pressure = 130mmH2O, CSF/ serum glucose ratio = 0.7, mononuclear leukocytosis (200/mm3) • CSF/ serum glucose ratio = 0.4, high protein, cells (PMN and mono) = 150/mm3

  6. What are the 3 components of meningismus?

  7. What are the 3 components of meningismus? • nuchal rigidity, meningeal irritation, headache • photophobia, nuchal rigidity, headache • headache, nuchal rigidity, fever • fever, photophobia, nuchal rigidity

  8. Describe Kernig’s and Brudzinski’s signs.

  9. Describe Kernig’s and Brudzinski’s signs. Kernigs - leg is bent at the hip and knee at 90 degree angles, and subsequent extension in the knee is painful (leading to resistance) Brudzinski’s - appearance of involuntary lifting of the legs in meningeal irritation when lifting a patient's head off the examining couch, with the patient lying supine

  10. Aciclovir’s mechanism of action is:

  11. Aciclovir’s mechanism of action is: • Prodrug nucleoside analogue that inhibits viral DNA polymerase after phosphorylation, resulting in chain termination. • Inhibition of viral protease used to cleave nascent proteins for assembly of new virions. • Binding to viral neuraminidase, rendering the influenza virus unable to escape its host cell and infect others. • interference with a viral M2 ion channel which is required for the viral particle to become "uncoated" once taken inside a cell by endocytosis.

  12. SPOT DIAGNOSIS! A 45 year old female from nimbin presents with loss of coordination (with high stepping gait), urinary incontinance, impaired pupil reaction to light, lower limb areflexia and lower back pain that shoots down her legs sometimes. There has been no recent illness or infections, but she says that 5 years ago she did have a ‘sore’ down there.

  13. SPOT DIAGNOSIS! A 45 year old female from nimbin presents with loss of coordination (with high stepping gait), urinary incontinance, impaired pupil reaction to light, lower limb areflexia and lower back pain that shoots down her legs sometimes. There has been no recent illness or infections, but she says that 5 years ago she did have a ‘sore’ down there. • GuillainBarre Syndrome • Myasthenia gravis • Tabesdorsalis • HIV/ AIDS

  14. VZV reactivation involving the facial and auditory nerves is known as:

  15. VZV reactivation involving the facial and auditory nerves is known as: • Bell’s palsy • Ramsay Hunt Syndrome • Trigeminal neuralgia • Postherpetic neuralgia

  16. What is the most helpful ‘clinical triad’ for diagnosis of GBS?

  17. What is the most helpful ‘clinical triad’ for diagnosis of GBS? • Areflexia, lower back pain radiating to legs, fever • Ascending flaccid paralysis, areflexia, respiratory distress or autonomic dysfunction • Respiratory distress, positive Campylobacter jejuni serum Ig, areflexia • Cytoalbumin dissociation, areflexia, ascending flaccid paralysis

  18. SPOT DIAGNOSIS! A new patient, a 40 year old man presents with left sided ptosis and diplopia. He also has dysphagia and his wife adds that he is slurring his speech (you just thought it was normal for him). All other examinations are normal.

  19. SPOT DIAGNOSIS! A new patient, a 40 year old man presents with left sided ptosis and diplopia. He also has dysphagia and his wife adds that he is slurring his speech (you just thought it was normal for him). All other examinations are normal. • Eaton-Lambert syndrome • Multiple Sclerosis • Stroke • Myasthenia gravis

  20. Why does thymectomy help some patients with myasthenia gravis?

  21. Why does thymectomy help some patients with myasthenia gravis? Something about knocking out the activation of T-helper cells that activate B-cells to plasma cells which then throw out the Ig against the Ach receptor….?

  22. What drugs are used to treat Myasthenia gravis? Why?

  23. What drugs are used to treat Myasthenia gravis? Why? • Atropine • Penicillin • Pyridostigmine • Oxybutinin

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