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Dr. Robert W. Fulton McCasland Foundation Endowed Chair for Food Animal Research Oklahoma State University

Bovine Viral Diarrhea Virus Variability and Prevalence of BVDV Subtypes in Persistently Infected Cattle Entering Feedlots: BVDV1b as Predominant Subtype. Dr. Robert W. Fulton McCasland Foundation Endowed Chair for Food Animal Research Oklahoma State University. B. V. D. V. 1. b. -. N.

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Dr. Robert W. Fulton McCasland Foundation Endowed Chair for Food Animal Research Oklahoma State University

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  1. Bovine Viral Diarrhea Virus Variability and Prevalence of BVDV Subtypes in Persistently Infected Cattle Entering Feedlots: BVDV1b as Predominant Subtype Dr. Robert W. Fulton McCasland Foundation Endowed Chair for Food Animal Research Oklahoma State University

  2. B V D V 1 b - N Y - 1 9 5 . 6 % B V D V 1 b - H a s t 9 3 . 5 % B V D V 1 b - T G A N 8 3 . 3 % B V D V 1 a - N A D L 9 7 . 8 % B V D V 1 a - S i n g e r 8 4 . 9 % B V D V 1 a - C 2 4 V B V D V 2 b - V S - 2 6 0 9 4 . 1 % B V D V 2 b - V S - 6 3 9 0 . 2 % B V D V 2 b - S o l d a n 7 9 . B V D V 2 a - 8 9 0 9 3 . 0 % B V D V 2 a - 2 9 6 n c 8 8 . 7 % B V D V 2 a - 1 2 5 n c BVDV Subgenotypes BVDV1b BVDV1a 6 2 . 7 % BVDV2b 2 % BVDV2a Dr. Julia Ridpath, USDA, ARS, NADC

  3. BVDV PI studies: OSU 1999-2009 with BVDV1b • 1999 – PI calf • in retained ownership program entering feedlot. • 1999-2000 –SE US calves to feedlot :BRD • 1999 study: PI calf, BVDV 1b , BRD disease • Nasal swabs, PBL, lung isolates, BVDV1b • Can J Vet Research, 2002, 66: 181-190

  4. BVDV PI studies: OSU 1999-2009 with BVDV1b • 2005- Subtypes in Diagnostic Laboratory Accessions. Vet Microbiology, 2005, 111,35-40 • Subtypes • BVDV1b: 45.8% • BVDV1a: 28.2% • BVDV2a: 26.0% • Categories of Disease : all subtypes involved • Respiratory, digestive, mixed/multiple, abortions • Persistent Infections

  5. BVDV Subtypes in PI Cattle in SW Kansas Feedlot: 2007-2008 • PI cattle: 0.4% 86/21,743 JAVMA , 2006,228: 578-584

  6. BVDV Subtypes in PI Cattle Entering SW Kansas Feedlot

  7. BVDV Subtypes in PI Cattle in Oklahoma Feedlot: 2007-2008 • PI cattle: 0.4% 30/7497

  8. BVDV Subtypes in Beef Breeding Herd Study for PI calves : 2006 • 30 herds with 5 herds positive: 16.7% • 25/ 4530 calves as PI= 0.55% • Three herds with single PI and 2 with multiple (10 and 12) • One dam of PI calves: PI (4.0%) • All PI isolates as BVDV1b Can J Vet Res, 2009 in press

  9. >99.9% similarity BVDV1b BVDV PI strains from 2006 NF BPS Survey

  10. Vaccines and BVDV Subtypes and Biotypes

  11. Vaccines and BVDV Subtypes and Biotypes

  12. Diversity of BVDV Antibodies in Vaccinated Cattle: Two Doses with BVDV1a and 2a strains

  13. Implications of Diversity of BVDV: Diagnostic Tests • Impact on Diagnostic Test for Antigen Detection • Monoclonal selection: epitopes : potential changes in epitope genome region may affect reactivity and diagnosis • IHC and ACE • FA • Viral genome differences for PCR tests

  14. Vaccines Against Multiple BVDV Subtypes • US and Canada : BVDV1a and BVDV2a strains • Demonstrate protection against acute challenge for multiple subtypes, ie BVDV1b • Demonstrate protection against fetal challenge for multiple subtypes, ie BVDV1b • Potential for BVDV1b monovalent or combination with BVDV1a and BVDV2a • Novel vaccines with multiple strains, genomic regions or protein subunits from different strains

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