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ITIM canonical [I/V/L]x Y(p) xx[I/V/L]

125. 125. H.sapience TDFQTLDGSQ Y NPV KQQLVRYAT M.musculus TDFQTLDGSQ Y NPVKQQLERYAT R.norvegicus TDFQTLDGSQ Y NPVKQQLERYAT S.Scrofa TDFQTLDGSQ Y NPVKQQLERYAT B.taurus TDFQTLDGSQ Y NP A KQQLERYAT. H.sapience TDFQTLDGSQ Y NPV KQQLVRYAT

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ITIM canonical [I/V/L]x Y(p) xx[I/V/L]

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  1. 125 125 H.sapience TDFQTLDGSQYNPVKQQLVRYAT M.musculus TDFQTLDGSQYNPVKQQLERYAT R.norvegicus TDFQTLDGSQYNPVKQQLERYAT S.Scrofa TDFQTLDGSQYNPVKQQLERYAT B.taurus TDFQTLDGSQYNPAKQQLERYAT H.sapience TDFQTLDGSQYNPVKQQLVRYAT M.musculus TDFQTLDGSQYNPVKQQLERYAT R.norvegicus TDFQTLDGSQYNPVKQQLERYAT S.Scrofa TDFQTLDGSQYNPVKQQLERYAT B.taurus TDFQTLDGSQYNPAKQQLERYAT A. A. ITIM canonical [I/V/L]xY(p)xx[I/V/L] ITIM like motifs [G/S/T/hydrophilic]xY(p)xx[I/V/L] ITIM like CoASy motif SQY(p)NPV ITIM canonical [I/V/L]xY(p)xx[I/V/L] ITIM like motifs [G/S/T/hydrophilic]xY(p)xx[I/V/L] ITIM like CoASy motif SQY(p)NPV B. B. Supl. Fig. 1. Schematic representation of potential ITIM interaction site for Shp2PTP on CoASy. (A) CoASy posseses conserved ITIM-like motif. Canonical ITIM, ITIM-like and CoASy ITIM-like motifs are presented with Y residue important for binding highlighted in red, X - any amino acid residue. (B) Conservation of Y125 among mammals. Sequences of amino acid sequence of CoASy derived from H. sapiens, M. musculus, R. norvegicus, S. scrofa, B. taurus were aligned using ClustalW. Identical amino acids are shown in black, while similar – in grey, residue Y125 is highlighted in red.

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