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Lecture Outline 10/26/05

Lecture Outline 10/26/05. Consequences of meiosis Gametes are genetically variable Independent assortment Crossing over Lots of practice problems Errors in meiosis Why reproduce sexually?. Mitosis vs meiosis:. Mitosis ensures exact replication of the parent cell

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Lecture Outline 10/26/05

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  1. Lecture Outline 10/26/05 • Consequences of meiosis • Gametes are genetically variable • Independent assortment • Crossing over • Lots of practice problems • Errors in meiosis • Why reproduce sexually?

  2. Mitosis vs meiosis: • Mitosis ensures exact replication of the parent cell • Meiosis produces variable, haploid, gametes. • Gametes are not identical, because of: • Independent assortment • Crossing over

  3. Independent Assortment • For each pair of chromosomes, maternal and paternal homologues are sorted into daughter cells independently of the other pairs Key Maternal set of chromosomes Possibility 1 Possibility 2 Paternal set of chromosomes Two equally probable arrangements of chromosomes at metaphase I Metaphase II Daughter cells Combination 1 Combination 2 Combination 3 Combination 4 Figure 13.10

  4. Consequences for genetic variation • Label two alleles of a gene “R” and “r” Red vs white feathers • Another gene on a different chromosome: “B” and “b” Barred vs non-barred feathers r R This individual inherited a chromosomes with alleles for Red feathers and non-barred feathers its father B b White feathers and barred feathers from its mother

  5. Consequences for genetic variation What kinds of gametes will it produce through independent assortment? r R B b

  6. Crossing Over Prophase I of meiosis Nonsister chromatids • Produces recombinant chromosomes that carry genes derived from two different parents Tetrad Chiasma, site of crossing over Metaphase I Metaphase II Daughter cells Recombinant chromosomes Figure 13.11

  7. The location of crossovers is random This tetrad has 3 crossovers: 2&3 1&3 2&4 Can occur between any pair of chromatids

  8. Spindle fibers from one pole attach to BOTH sister chromatids Spindle fibers from the other pole attach to the other homolog Crossovers are essential for correct alignment at metaphase 1 Chiasmata hold the pair together while “Tug of war” Aligns tetrads

  9. Crossovers are random • If two genes are close together on the chromosome, they are likely to be inherited together. D A B A B d a b D a b d

  10. Red vs white feathers Consequences for genetic variation Brown vs white eggs R Br Br r br R br r What kinds of gametes can it produce?

  11. b D d a A B a A b B d D Test yourself: Assume the individual is diploid with 3 pairs of chromosomes A||a B||b D||d Is this mitosis or meiosis? Why? What stage?

  12. a b D b A D A a b B d d What is wrong with this picture? Again, assume the individual is diploid with 3 pairs of chromosomes A||a B||b D||d

  13. A b D b D A A b D A b D B a d a B d B B d a a d What is wrong with this picture?

  14. a b D b A D A a b B d d a d b d b a A D B D B A More practice Mitosis or meiosis? Is it correct? Mitosis or meiosis? Is it correct?

  15. b A a D A D A b D B a d a b B d B d A b D a B D b A d a B d a b d a b d a d b a b d Even more practice

  16. Errors in meiosis • Polyploidy • duplications of entire genomes • Seen in many plant species • Consequences for reproductive isolation • AAAA x AA --> AAA • How does meiosis work in that triploid? • Sterile

  17. Errors in meiosis • Aneuploidy • duplications or deletions of single chromosomes

  18. Errors in meiosis: aneuploidy • Most human aneuploids are fatal. • Exception: trisomy 21 (Downs Syndrome) • Exception: XXY Turner’s syndrome males

  19. Natural variation in chromosome number • Species differ greatly in chromosome number: • E. coli: 1 circular chromosome • Drosophila melanogaster: 4 chromosomes • Wood fern: 2N=164 Chimps and gorillas have 2N=48 Humans have 2N=46 • How would that affect reproduction in pre-hominid/pre-chimp ancestors? • Imagine meiosis and the duplication/deletions that would be in the hybrid zygotes • How would the hybrid (2N=47) make gametes? How would chromosomes pair?

  20. Why sex? Disadvantages: • Need to find a mate • Only pass on half of your genes • That new combination of genes might be worse . . . Advantages of sex: • Avoid disease • Don’t purchase the same lottery ticket twice • Purge mutations

  21. Advantages of sex: Avoid disease • Bananas are propagated asexually • “Cavendish” variety accounts for almost all of the commercial bananas • Panama disease (Fusarium wilt) is spreading through Asia • It’s predecessor variety, the “Gros Michel” suffered a similar fungal blight that wiped out that crop in the 1950s

  22. One solution: Breed resistant varieties • Imagine that two parental varieties differ in 15 single genes. To get the desired allele at each locus, 0.515 = 1/30,000 http://www.popsci.com

  23. That’s a lot of bananas . . . http://www.uga.edu/fruit/banana.htm

  24. Some organisms have both sexual and asexual stages

  25. Advantages of sex • Purge deleterious mutations • Mutations occur every generation • Over time, each chromosome will accumulate several deleterious mutations • Without meiosis, the number of mutations on a chromosome will only increase Most of them are deleterious Different lineages will acquire different mutations - + + + - + + + - + + - Crossing over can produce some gametes with fewer mutations ++++-

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