Cutting-Edge Chemistry Research at IOC NAS Ukraine

1. Institute of Organic Chemistry National Academy of Sciences of Ukraine Innovative Opportunities and Prospects Murmanska str., 5, 02660, Кyiv-94 www.ioch.kiev.ua

2. The Institute’s Employees

3. The Institute’s Scientific Department 1. Organophosphorus Compounds2. Heteroatom Chemistry3. Colour and Structure of Organic Compounds4. Mechanisms of Organic Reactions5. Chemistry of Phosphoranes 6. Chemistry of Bio-active Compounds7. Physico-chemical Investigations8. Chemistry of Organo-fluorine Compounds9. Chemistry of Organo-sulfur Compounds 10. Bio-medical Investigations

4. TheInstitute’s Basic Research • fine organic synthesis • organoelement chemistry (P, S, Si) • heterocyclic chemistry • fluoroorganic chemistry • polymethyne dyes, colour theory • mechanisms of organic reactions • chemistry of biologically active compounds • supramolecular chemistry • calixarene chemistry

5. Patent activity in 2013

6. Fluorination reagents and processes

7. DEVELOPMENT OF THE ACID SENSING ION CHANNELS ANTAGONISTS WITH NEUROPROTECTIVE ANTIISCHEMIC PROPERTIES IN COOPERATION WITH BOGOMOLETZ INSTITUTE OF PHYSIOLOGY NAS OF UKRAINE KMS-005 IC50 = 27 nM Known blocker Amiloride IC50 = 4000 nM X-ray Structure of Acid Sensing Ion Channel 1a Ukraine patent № 66987; Fiziol. Zh. 2011, 57, 6, 31

8. New nano-sized catalytic compositions for selective chlorinationof alkylaromatic compounds Innovative Aspect and Advantages New catalytic compositions based on thiocrown-ethers and Lewis catalysts (SbCl5, SbCl3, FeCl3) provide better yields of para-chlorotoluene in comparison with the known industrial Lewis Acid catalytic compositions Structure of the nano-catalyst SbCl5–benzodithio-18-crown-6 – Cl2 Products of toluene chlorination with usage of the nano-catalyst Patent of Ukraine № И201104813

9. Solvatochromism and passive mode locking of erbium laser o-C6H4Cl2 (a). Oscillogram of trains which arise on a background of spikes of free generation. (b). The ultrashort pulse of the passively mode-locked laser on Yb-Er glass (λ= 1540 nm) with saturable absorber based on dye 4919u. MeCN

10. Photothermoplastic holographic composite Merocyanine (D–A) Detection of internal microcrack in a railroad rail. The hologram was recorded usinb the polymer film doped with merocyanine D–A Dependency of photoconductivity JPH on electric field strength E in Al/PEPK + 0.5 mass % dye / SnO2 sample (thickness = 1.2 μm, I = 8 W•m–2)

11. CALIXARENE RECEPTORS Calixarenes selectively recognize, bind and separate similar in properties species

12. Institute of Organic Chemistry NAS Ukraine Calixarene R&D Research Design of selective (chiral) receptors of cations, anions, molecules and bio-molecules Development Radionuclide Extractants Chemosensors Drug Design J. Am. Chem. Soc. 2007. 129. 1123-1131. J. Org. Chem. 2007. 72. 3223-3231. Pure Appl. Chem. 2008. 80. 1449-1458 J. Phys. Chem. C. 2009. 113. 1137-1142 Curr. Med. Chem. 2009. 16. 1630-1655 Bioorg. Med. Chem. Lett. 2010, 20, 483–487 J.of Catalysis. 2011.284. 42-49 FEBS Journal. 2011. 278. 1244-1251

13. Actinides extractionDistribution D between nitrobenzotrifluoride and HNO3 (0.3M) Smirnov I. V., KaravanM. D., Efremova T. I., Babain V. A., Miroshnichenko S. I., Cherenok S. A., Kalchenko V. I. Radiochemistry. 2007. 49. 423-431

14. Calixarene Micellar Complex Hydrophilic Rim radionuclide Hydrophobic Rim Amphiphilic Calixarenes

15. Micelle-mediated purification of radioactive water Ultrafiltration, or cloud point extraction radioactive water micellar complexes radioactive water purified water Patent of Ukraine.28405. 2007 Russian patent. 2343161. 2007

16. Calixarene bis-Quinazolinone - Methanol Complex Rodik R., Rozhenko A., Boyko V., Pirozhenko V., Danylyuk O., Suwinska K., Lipkowski J., Kalchenko V. Tetrahedron. 2007. 63. 11451-11457.

17. Calixarene phosphonous acids as receptors for biomolecules

18. Наукові та виробничі зв'язки з підприємствами України

19. Діяльність Дослідного виробництва

20. ДЯКУЮ ЗА УВАГУ !