1 / 9

Disease Acute leukemia Chronic leukemia Non-Hodgkin’s lymphoma Myeloma

Disease Acute leukemia Chronic leukemia Non-Hodgkin’s lymphoma Myeloma. Usual phenotype Precursor Differentiated. Chronic Lymphocytic Leukemia. Most common leukemia Usually age > 50 yrs Progressive accumulation of neoplastic, immunologically incompetent, clonal lymphocytes

nanda
Download Presentation

Disease Acute leukemia Chronic leukemia Non-Hodgkin’s lymphoma Myeloma

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Disease Acute leukemia Chronic leukemia Non-Hodgkin’s lymphoma Myeloma Usual phenotype Precursor Differentiated

  2. Chronic Lymphocytic Leukemia • Most common leukemia • Usually age > 50 yrs • Progressive accumulation of neoplastic, immunologically incompetent, clonal lymphocytes • B cell origin > 98% • T cell 1-2%

  3. Clinical Features of CLL • Highly variable presentation • Asymptomatic, or vague, non-specific complaints • Recurrent infection 10% (often pneumococcus) • Signs • Lymphadenopathy (60%) • Splenomegaly (50%) • Hepatomegaly (< 40%)

  4. Clinical Features of CLL • Laboratory • blood and marrow lymphocytosis • B cell monoclonality: k vs l surface light chain single Ig gene rearrangement • hypoimmunoglobulinemia • Prognosis • Mean survival = 50-60 months • Range = few months to > 20 yrs

  5. Immunological Abnormalities in CLL • Disturbed Ab production • Hypogammaglobulinemia (50%)  bacterial infection • Decrease in one or more Ig fraction (80%) • Monoclonal paraprotein in serum (10%) • Autoantibodies (10%) • Minor impairments in cell-mediated immunity • Neoplastic lymphocytes • Monoclonal surface Ig • Abnormal response to Ig challenge

  6. Complications of CLL

  7. Rai Staging System for CLL

  8. Treatment of CLL • No evidence that therapy prolongs survival • Asymptomatic: watch and wait • Symptomatic: • Radiation for local complications • Chemotherapy: fludarabine, alkylators, combinations • Monoclonal antibodies (eg, Campath) • Stem cell transplantation

More Related