20 likes | 185 Views
NR1. NR2. allosteric modulators site 1. site 2 ?. N-terminal domains (NTDs). Zn 2+ (NR2A>>NR2B) ifenprodil (NR2B). site 3 ?. agonist -binding domains (ABDs). competitive agonists and antagonists. glycine (or D-serine). glutamate. site 4 ?. pore blockers. pore domains. 4.
E N D
NR1 NR2 allosteric modulators site 1 site 2 ? N-terminal domains (NTDs) Zn2+ (NR2A>>NR2B) ifenprodil (NR2B) site 3 ? agonist -binding domains (ABDs) competitive agonists and antagonists glycine (or D-serine) glutamate site 4 ? pore blockers pore domains 4 1 3 3 1 4 2 2 C-terminal domains