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Chew On this

Chew On this. A nurse’s guide to teaching the oncologist averse what to eat and why. Bianca Moses Fall 2012. Cancer Primer. Cancer Primer. Cancer is just:. Cancer Primer. Cancer is just:. Cancer Primer. Cancer is just: a cluster of AWOL cells. Cancer Primer. Cancer is just:

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Chew On this

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  1. Chew On this A nurse’s guide to teaching the oncologist averse what to eat and why Bianca Moses Fall 2012

  2. Cancer Primer

  3. Cancer Primer • Cancer is just:

  4. Cancer Primer • Cancer is just:

  5. Cancer Primer • Cancer is just: • a cluster of AWOL cells

  6. Cancer Primer • Cancer is just: • a cluster of AWOL cells • that happened to get together one day

  7. Cancer Primer • Cancer is just: • a cluster of AWOL cells • that happened to get together one day

  8. Cancer Primer • Cancer is just: • a cluster of AWOL cells • that happened to get together one day • and decide to re-appropriate real estate from the tissues of your body

  9. Cancer Primer • Cancer is just: • a cluster of AWOL cells • that happened to get together one day • and decide to re-appropriate real estate from the tissues of your body • so that they could establish their own sick cancer commune.

  10. Cancer Primer • Cancer is just: • a cluster of AWOL cells • that happened to get together one day • and decide to re-appropriate real estate from the tissues of your body • so that they could establish their own sick cancer commune.

  11. Cancer Primer • Obviously, these aren’t cells that play by the rules!

  12. Cancer Primer • Obviously, these aren’t cells that play by the rules! • These cancer cells have tempers

  13. Cancer Primer • Obviously, these aren’t cells that play by the rules! • These cancer cells have tempers • and they get pushy

  14. Cancer Primer • Obviously, these aren’t cells that play by the rules! • These cancer cells have tempers • and they get pushy • and they grow into and on top of the polite body cells

  15. Cancer Primer • Obviously, these aren’t cells that play by the rules! • These cancer cells have tempers • and they get pushy • and they grow into and on top of the polite body cells • …with complete disregard for these nice body cell’s personal space bubbles

  16. Cancer Primer • Obviously, these aren’t cells that play by the rules! • These cancer cells have tempers • and they get pushy • and they grow into and on top of the polite body cells • …with complete disregard for these nice body cell’s personal space bubbles

  17. Cancer Primer • Once their numbers become so plentiful that they reach the verge of dying from starvation

  18. Cancer Primer • Once their numbers become so plentiful that they reach the verge of dying from starvation • They send out chemicals to cause blood vessels to grow directly into their tumor commune

  19. Cancer Primer • Once their numbers become so plentiful that they reach the verge of dying from starvation • They send out chemicals to cause blood vessels to grow directly into their tumor commune VEGF

  20. Cancer Primer • Once their numbers become so plentiful that they reach the verge of dying from starvation • They send out chemicals to cause blood vessels to grow directly into their tumor commune VEGF: Vascular Epithelial Growth Factor

  21. Cancer Primer • Once their numbers become so plentiful that they reach the verge of dying from starvation • They send out chemicals to cause blood vessels to grow directly into their tumor commune VEGF: Vascular Epithelial Growth Factor

  22. Cancer Primer • Once their numbers become so plentiful that they reach the verge of dying from starvation • They send out chemicals to cause blood vessels to grow directly into their tumor commune VEGF: Vascular Epithelial Growth Factor

  23. Cancer Primer • Once their numbers become so plentiful that they reach the verge of dying from starvation • They send out chemicals to cause blood vessels to grow directly into their tumor commune VEGF: Vascular Epithelial Growth Factor

  24. Cancer Primer • Once their numbers become so plentiful that they reach the verge of dying from starvation • They send out chemicals to cause blood vessels to grow directly into their tumor commune VEGF: Vascular Epithelial Growth Factor

  25. Cancer Primer • Once their numbers become so plentiful that they reach the verge of dying from starvation • They send out chemicals to cause blood vessels to grow directly into their tumor commune • Without vessels, tumors grow no larger than a pea VEGF: Vascular Epithelial Growth Factor

  26. Cancer Primer • Once their numbers become so plentiful that they reach the verge of dying from starvation • They send out chemicals to cause blood vessels to grow directly into their tumor commune • Without vessels, tumors grow no larger than a pea • With vessels, tumors become huge, break off and use those same vessels as highways to metastasize all over the body VEGF: Vascular Epithelial Growth Factor

  27. Cancer Primer • Tumors initiating a blood supply is called ANGIOGENESIS VEGF: Vascular Epithelial Growth Factor

  28. Cancer Primer • Tumors initiating a blood supply is called ANGIOGENESIS • We have found drugs to inhibit and reverse angiogenesis VEGF: Vascular Epithelial Growth Factor

  29. Cancer Primer • Tumors initiating a blood supply is called ANGIOGENESIS • We have found drugs to inhibit and reverse angiogenesis VEGF: Vascular Epithelial Growth Factor Avastin Itraconazole Carbocyamidotriaole Prolactin TNP-470 CM101 IFN-α Tecogalan Linomide IL-12 Platelet Factor 4 Suramin Lucentis Thrombospondin Angiostatin Endostatin Linomide 2-Methoxyestradiol And many more…

  30. Anti-Angiogenesis • Tumors initiating a blood supply is called ANGIOGENESIS • We have found drugs to inhibit and reverse angiogenesis VEGF: Vascular Epithelial Growth Factor Avastin Itraconazole Carbocyamidotriaole Prolactin TNP-470 CM101 IFN-α Tecogalan Linomide IL-12 Platelet Factor 4 Suramin Lucentis Thrombospondin Angiostatin Endostatin Linomide 2-Methoxyestradiol And many more…

  31. Anti-Angiogenesis • Tumors initiating a blood supply is called ANGIOGENESIS • We have found drugs to inhibit and reverse angiogenesis VEGF: Vascular Epithelial Growth Factor Avastin Itraconazole Carbocyamidotriaole Prolactin TNP-470 CM101 IFN-α Tecogalan Linomide IL-12 Platelet Factor 4 Suramin Lucentis Thrombospondin Angiostatin Endostatin Linomide 2-Methoxyestradiol And many more…

  32. Block VEGF receptors on intercepting blood vessels Anti-Angiogenesis • Tumors initiating a blood supply is called ANGIOGENESIS • We have found drugs to inhibit and reverse angiogenesis VEGF: Vascular Epithelial Growth Factor Avastin Itraconazole Carbocyamidotriaole Prolactin TNP-470 CM101 IFN-α Tecogalan Linomide IL-12 Platelet Factor 4 Suramin Lucentis Thrombospondin Angiostatin Endostatin Linomide 2-Methoxyestradiol And many more…

  33. Block VEGF receptors on intercepting blood vessels Bind to VEGF in circulation preventing receptor binding Anti-Angiogenesis • Tumors initiating a blood supply is called ANGIOGENESIS • We have found drugs to inhibit and reverse angiogenesis VEGF: Vascular Epithelial Growth Factor Avastin Itraconazole Carbocyamidotriaole Prolactin TNP-470 CM101 IFN-α Tecogalan Linomide IL-12 Platelet Factor 4 Suramin Lucentis Thrombospondin Angiostatin Endostatin Linomide 2-Methoxyestradiol And many more…

  34. Block VEGF receptors on intercepting blood vessels Bind to VEGF in circulation preventing receptor binding Travel through vessels to stop tumor from secreting more VEGF Anti-Angiogenesis • Tumors initiating a blood supply is called ANGIOGENESIS • We have found drugs to inhibit and reverse angiogenesis VEGF: Vascular Epithelial Growth Factor Avastin Itraconazole Carbocyamidotriaole Prolactin TNP-470 CM101 IFN-α Tecogalan Linomide IL-12 Platelet Factor 4 Suramin Lucentis Thrombospondin Angiostatin Endostatin Linomide 2-Methoxyestradiol And many more…

  35. Block VEGF receptors on intercepting blood vessels Bind to VEGF in circulation preventing receptor binding Travel through vessels to stop tumor from secreting more VEGF Anti-Angiogenesis • Tumors initiating a blood supply is called ANGIOGENESIS • We have found drugs to inhibit and reverse angiogenesis VEGF: Vascular Epithelial Growth Factor Avastin Itraconazole Carbocyamidotriaole Prolactin TNP-470 CM101 IFN-α Tecogalan Linomide IL-12 Platelet Factor 4 Suramin Lucentis Thrombospondin Angiostatin Endostatin Linomide 2-Methoxyestradiol And many more…

  36. Block VEGF receptors on intercepting blood vessels Bind to VEGF in circulation preventing receptor binding Travel through vessels to stop tumor from secreting more VEGF Anti-Angiogenesis • Tumors initiating a blood supply is called ANGIOGENESIS • We have found drugs to inhibit and reverse angiogenesis • No blood supply = VEGF: Vascular Epithelial Growth Factor Avastin Itraconazole Carbocyamidotriaole Prolactin TNP-470 CM101 IFN-α Tecogalan Linomide IL-12 Platelet Factor 4 Suramin Lucentis Thrombospondin Angiostatin Endostatin Linomide 2-Methoxyestradiol And many more…

  37. Block VEGF receptors on intercepting blood vessels Bind to VEGF in circulation preventing receptor binding Travel through vessels to stop tumor from secreting more VEGF Anti-Angiogenesis • Tumors initiating a blood supply is called ANGIOGENESIS • We have found drugs to inhibit and reverse angiogenesis • No blood supply = No TUMOR VEGF: Vascular Epithelial Growth Factor Avastin Itraconazole Carbocyamidotriaole Prolactin TNP-470 CM101 IFN-α Tecogalan Linomide IL-12 Platelet Factor 4 Suramin Lucentis Thrombospondin Angiostatin Endostatin Linomide 2-Methoxyestradiol And many more…

  38. Block VEGF receptors on intercepting blood vessels Bind to VEGF in circulation preventing receptor binding Travel through vessels to stop tumor from secreting more VEGF Anti-Angiogenesis • Tumors initiating a blood supply is called ANGIOGENESIS • We have found drugs to inhibit and reverse angiogenesis • No blood supply = No TUMOR VEGF: Vascular Epithelial Growth Factor Avastin Itraconazole Carbocyamidotriaole Prolactin TNP-470 CM101 IFN-α Tecogalan Linomide IL-12 Platelet Factor 4 Suramin Lucentis Thrombospondin Angiostatin Endostatin Linomide 2-Methoxyestradiol And many more…

  39. Anti-Angiogenesis Dr.JudahFolkman

  40. 1971 Anti-Angiogenesis Dr.JudahFolkman

  41. 1971 Anti-Angiogenesis • Hypothesized and subsequently proved that: Dr.JudahFolkman

  42. 1971 Anti-Angiogenesis • Hypothesized and subsequently proved that: • Tumor growth is angiogenesis dependent Dr.JudahFolkman

  43. 1971 Anti-Angiogenesis • Hypothesized and subsequently proved that: • Tumor growth is angiogenesis dependent • Tumors secreted angiogenic factors Dr.JudahFolkman

  44. 1971 Anti-Angiogenesis • Hypothesized and subsequently proved that: • Tumor growth is angiogenesis dependent • Tumors secreted angiogenic factors • Blocking these factors inhibited tumor growth Dr.JudahFolkman

  45. 1971 Anti-Angiogenesis Dr.William Li • Hypothesized and subsequently proved that: • Tumor growth is angiogenesis dependent • Tumors secreted angiogenic factors • Blocking these factors inhibited tumor growth Dr.JudahFolkman

  46. Anti-Angiogenesis Dr.William Li • Protégé of Dr.Folkman and continued on with his research

  47. Anti-Angiogenesis Dr.William Li

  48. Anti-Angiogenesis Dr.William Li

  49. Anti-Angiogenesis Dr.William Li

  50. Anti-Angiogenesis Dr.William Li

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