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Shear stress responsiveness in an embryonal chicken heart

Shear stress responsiveness in an embryonal chicken heart. M. Pourquie 1 , P. Vennemann 1 , B. Groenendijk 2 , B. Hierck 2 , S. Stekelenburg-de Vos 3 , N. Ursem 3 , R. Poelmann 2 , F. Nieuwstadt 1 ,J. Westerweel 1

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Shear stress responsiveness in an embryonal chicken heart

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  1. Shear stress responsiveness in an embryonal chicken heart M. Pourquie1, P. Vennemann1, B. Groenendijk2, B. Hierck2, S. Stekelenburg-de Vos3, N. Ursem3, R. Poelmann2, F. Nieuwstadt1 ,J. Westerweel1 1Laboratory for Aero & Hydrodynamics, Delft University of Technology,The Netherlands 2 LUMC, Leiden, The Netherlands 3Erasmus University, Rotterdam, The Netherlands 1. motivation 1. motivation 2. Chosen test case: a chicken embryo’s heart • Early detection of growth errors during heart development • Demonstrate and quantify relation between wall shear stress and growth errors, experimentally and numerically Chicken embryo and artery system V = Ventricle MC = Micro Clip length heart 1mm D heart 0.3mm 2. Gene expression of shear responsive genes 3. Gene expression of shear responsive genes 4. Micro PIV measurements Expression of shear stress responsive factor on reconstruction of heart showing places with high shear (blue) First measure-ments in a Vitelline vein, big arrows: Averaged flow profile Heart 5. Numerics: Curved boundary on Cartesian grid 6. Numerics: Surface Representation Heart • Curved boundary represented by adding additional source terms to momentum equations, such thatinterpolated velocities on curve have correct value Triangularization of boundary of heart interior (only right cushions contracted)

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