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Start (or continue) going to TA sections. Come to R ’ s and/or TAs office hours 2130 Pac Hall Tu 2:30-3:30 W 2: 30 -3: 30 . details on course web site:. http://course.ucsd.edu/rhampton/bibc102. Warburg Effect. the Warburg effect is the observation that most cancer cells
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Start (or continue) going to TA sections Come to R’s and/or TAs office hours 2130 Pac Hall Tu2:30-3:30 W 2:30-3:30 details on course web site: http://course.ucsd.edu/rhampton/bibc102
Warburg Effect the Warburg effect is the observation that most cancer cells predominantly produce energy by a high rate of glycolysis followed by lactic acid fermentation in the cytosol Otto Heinrich Warburg 1931 Nobel Prize in Medicine
Getting other sugars into the glycolytic pathway fig 14-10
Liberating glucose units from glycogen more about glycogen later fig 14-11
From glycogen to glycolysis… phosphogluco- mutase another mutase…
Now what? fig 14-1
Now what? fig 14-1
Now what? Fermentation: anaerobic metabolism of glucose without oxidation... fig 14-1
LDH converts pyruvate to lactate, restoring the pool of NAD+ pg 547
LDH converts pyruvate to lactate, restoring the pool of NAD+ pg 547
ethanol production: another NAD+ restoration strategy pg 547
TPP as a carbanion nucleophile in pyruvate metabolism fig 14-14
TPP as a carbanion nucleophile in pyruvate metabolism fig 14-14
TPP as a carbanion nucleophile in pyruvate metabolism fig 14-14
TPP-mediated enzymatic reactions TPP is all about carbonyl activation table 14-1
The glycolysis energy landscape (pyruvate set to 0)
Regulated glycolytic enzymes hexokinse (and glucokinse) regulated by G6P allosterically liver isozyme is glucokinase, different phosphofructokinase (PFK-1) pyruvate kinase regulated by ATP, citrate, and fatty acids
The glycolysis energy landscape (pyruvate set to 0)
PFK-1 : a right fancy enzyme! fig 15-14
FPK-1 has multiple allosteric regulators fig 15-14
Our book’s notation for regulators inhibition activation fig 15-14
PFK-1 has multiple allosteric regulators fig 15-14
Ask… or txt: 858 914 4945
Pentose phosphate pathway oxidative reactions Glucose as a source of other stuff fig 14-21
Pentose phosphate pathway oxidative reactions fig 14-21
Pentose phosphate pathway oxidative reactions fig 14-21
Pentose phosphate pathway oxidative reactions fig 14-21
Pentose phosphate pathway: non-oxidative rxns all movement of carbonyl groups to and fro… fig 14-22
Pentose phosphate pathway: non- oxidative reactions 2C 3C 2C 2C 2C 3C fig 14-22 end of lecture 6
LDH converts pyruvate to lactate, restoring the pool of NAD+ pg 547