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Steroid Receptor Biology

Steroid Receptor Biology. Prince Henry’s Institute Monash Medical Centre 246 Clayton Road, Clayton, Victoria Contacts: Dr. Morag Young: morag.young@princehenrys.org Prof. Peter Fuller: peter.fuller@princehenrys.org. Uninephrectomised mouse/rat treated with aldosterone/DOC

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Steroid Receptor Biology

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  1. Steroid Receptor Biology Prince Henry’s Institute Monash Medical Centre 246 Clayton Road, Clayton, Victoria Contacts: Dr. Morag Young: morag.young@princehenrys.org Prof. Peter Fuller: peter.fuller@princehenrys.org

  2. Uninephrectomised mouse/rat treated with aldosterone/DOC plus 0.9% saline 8 days Oxidative Stress NADPH oxidase Macrophages Inflammation Osteopontin COX-2 8 weeks Cardiac Hypertrophy Hypertension Cardiac Fibrosis Mineralocorticoid receptors (MR) and Heart Disease Dr Morag Young Heart disease is a leading cause of death in Australia (40%) MR are a key players in this pathology…but how?! We have 3 tissue selective MR knockout mouse strains that we are using to determine the specific role of the MR in heart

  3. Mineralocorticoid receptors (MR) and Heart Disease Dr Morag Young Endothelial cell MR-null mice: Reduced DOC-induced macrophage recruitment at 8 days Fibrillar collagen Endothelial cell Artery Fibroblast MR Cardiac myocyte VSMC MR MR Macrophage MR-null mice: No effect on DOC-induced monocyte/macrophage recruitment Reduced basal gene expression Cardiac myocyte MR-null mice: No effect on DOC-induced monocyte/macrophage recruitment No effect on inflammatory gene expression

  4. Granulosa Cell Tumours (GCT) Professor Peter Fuller • Comprise 5% of malignant ovarian tumours • Molecular analysis of tumour bank and cell lines • Tissue selective knockout of IKK signalling in ovaries • Our focus has been on: • profiles of gene expression: candidates & microarray • signalling pathways – constitutive activation • expression of ER • coregulatory molecules • ERβ-induced genes • mutation detection • Implications for normal granulosa cells

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