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ATEROSCLEROSI

ATEROSCLEROSI. Atherosclerosis is an inflammatory disease characterized by intense immunological activity, which increasingly threatens human health worldwide.

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ATEROSCLEROSI

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  1. ATEROSCLEROSI

  2. Atherosclerosis is an inflammatory disease characterized by intense immunological activity, which increasingly threatens human health worldwide. Atherosclerosis involves the formation in the arteries of lesions that are characterized by inflammation, lipid accumulation, cell death and fibrosis. Over time, these lesions, which are known as atherosclerotic plaques, mature and gain new characteristics. HANSON AND LIBBY Nature Reviews Immunology 6:508-519, 2006

  3. FATTORI DI RISCHIO E TEORIA DELLA REAZIONE AL DANNO

  4. L’inattivazione di geni codificanti per proteine implicate nel reclutamento monocitario riduce lo sviluppo di Lesioni ateroscelrotiche in topi con inattivazione genica di APOE o LDL-R CX3C, CXCR2, CCR2 b chain MCP-1 X X X X X von Andrian UH and Mackay CR N Engl J Med 343, 1020, 2000

  5. Nuclearproteins: • HMGB1 (high mobilitygroup box1 protein) • Histones • Cytosolicproteins: heat shock proteins Pathogen-associated molecular patterns Damage-associatedmolecularpatterns

  6. In seguito all’esposizione ad endotossine le piastrine interagiscono (???) con PMN inducendo la formazione di NETs TLR4 Formazione di NETs Danno endoteliale batteri

  7. APPROCCI PREVENTIVI E TERAPEUTICI Inizio lesione: eliminazione “cause” Stabilizzazione della placca Progressione della placca: inibizione formazione di placca “instabile” Complicanze trombotiche: riduzione fattori favorenti formazione di trombi

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