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Chapter 7 Outline. 7.1 Linked Genes Do Not Assort Independently, 161 7.2 Linked Genes Segregate Together, and Crossing Over Produces Recombination between Them, 162 7.3 A Three-Point Testcross Can Be Used to Map Three Linked Genes, 175
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Chapter 7 Outline • 7.1 Linked Genes Do Not Assort Independently, 161 • 7.2 Linked Genes Segregate Together, and Crossing Over Produces Recombination between Them, 162 • 7.3 A Three-Point Testcross Can Be Used to Map Three Linked Genes, 175 • 7.4 Physical Mapping Methods Are Used to Determine the Physical Positions of Genes on Particular Chromosomes, 185 • 7.5 Recombination Rates Exhibit Extensive Variation, 188
7.2 Linked Genes Segregate Together and Crossing Over Produces Recombination between Them
7.2 Linked Genes Segregate Together and Crossing Over Produces Recombination between Them • Notation for Crosses with Linkage • Complete Linkage Leads to Nonrecombinant Gametes and Nonrecombinant Progeny • Crossing Over with Linked Genes Lead to Recombiant Gametes and Recombinant Progeny
Calculating Recombination Frequency • Recombination frequency = (number of recombinant progeny / total number of progeny) × 100%
Coupling and Repulsion Configuration of Linked Genes • Coupling (cis configuration): Wild type alleles are found on one chromosome; mutant alleles are found on the other chromosome.
Coupling and Repulsion Configuration of Linked Genes • Repulsion (trans configuration): Wild-type allele and mutant allele are found on the same chromosome.
Concept Check 2 The following testcross produces the progeny shown: AaBb × aabb 10 AaBb, 40 aaBb, 40 aaBb, and 10 aabb. What is the percentage of recombination between the A and B loci? Were the genes in the AaBb parent in coupling or repulsion?
Concept Check 2 The following testcross produces the progeny shown: AaBb × aabb 10 AaBb, 40 aaBb, 40 aaBb, and 10 aabb. What is the percent recombination between the A and B loci? Were the genes in the AaBb parent in coupling or repulsion? % recombination: 20%; genes in the AaBb parent were in repulsion
Gene Mapping with Recombination Frequencies • Genetic maps are determined by recombinant frequency. • Map unit and centiMorgans
7.3 A Three-Point Testcross Can Be Used to Map Three Linked Genes • Constructing a Genetic Map with the Three-Point Testcross
Constructing a Genetic Map with the Three-Point Testcross • Determining the gene order • Determining the location of crossovers
Concept Check 3 Write the genotypes of all recombinant and nonrecombinant progeny expected from the following three-point cross:
Concept Check 3 Write the genotypes of all recombinant and nonrecombinant progeny expected from the following three-point cross: Answer: