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By Anthony Anastasio

The Effects of Resveratrol and Melatonin on Drosophila melanogaster with Paraquat Induced Oxidative Stress. By Anthony Anastasio. Need. Figure 1 Over the passed 6 years, disorders from alcohol have increased. Figure 2 Wine still remains the leased consumed alcoholic beverage.

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By Anthony Anastasio

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  1. The Effects of Resveratrol and Melatonin on Drosophila melanogaster with Paraquat Induced Oxidative Stress By Anthony Anastasio

  2. Need Figure 1 Over the passed 6 years, disorders from alcohol have increased Figure 2 Wine still remains the leased consumed alcoholic beverage

  3. Oxidative stress

  4. Antioxidants

  5. Resveratrol • Found in the skin of grapes that are used in the fermentation of red wine. • Found in plants as a defense system against disease.

  6. Bass (2007) • When drosophila exposed to resveratrol, no increase in lifespan is shown Effect of Resveratrol on the Life span of C. Elegans

  7. Bauer (2004)

  8. Bonilla and Molero (2006) • Drosophila exposed to Melatonin, Serotonin, Lipoic acid, and Ascorbic acid The survivability of Drosophila shown after paraquat induced oxidative stress with different pre exposures

  9. Purpose • To determine the effects of resveratrol and melatonin on the survival rate of drosophila after paraquat induced oxidative stress.

  10. Hypothesis • Null Hypothesis- Drosophila will have the same survival rate after paraquat induced oxidative stress in all groups and no change in life span will occur. • Alternative Hypothesis- Drosophila that are pre-exposed to resveratrol and melatonin will have a higher survival rate after paraquat induced oxidative stress and a longer life span then the control group.

  11. Budget

  12. Do-ability • Drosophila cultures are available • Exposure to Resveratrol and Melatonin • Procedures that been done in lab

  13. Bibliography • Bonilla, Enrnesto. “Paraquat-induced Oxidative Stress in Drosophila melanogaster: Effects of Melatonin, Glutathione, Serotonin, Minocycline, Lipoic Acid and Ascorbic Acid” 2006 <http://www.springerlink.com/content/t94348024gm18223/fulltext.pdf> • Goodwin, Tony. "Our Model: The Fruitfly Drosophila melanogaster." 14 Feb 2005 <http://www.anatomy.unimelb.edu.au/researchlabs/whitington/index.html#top>. • Hurst , Greg. "Insects, Sex and Parasites Group." http://www.ucl.ac.uk/~ucbtghu/Greg.htm • Kimball, John. "Drosophila melanogaster." 13 Nov 2002 <http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/D/Drosophila.html. • Mann, Chris. "tea: a cup full of health and happiness." Better Nutrition. 01 Mar 2007. 58. • Manning, Gerald. "A quick and simple introduction to Drosophila melanogaster." (2006) <http://www.ceolas.org/fly/intro.html>. • Roberfroid, Marcel. "Prebiotics: The Concept Revisited1,2." Journal of Nutrition. 3 2007. 830S. • Turner, Oliver. "Herbal Tea Benefits." 17 Mar 2006 <http://www.buzzle.com/editorials/3-14-2006-91095.asp>.

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