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Christoph Schramm, Ansgar W. Lohse I. Medizinische Klinik und Poliklinik

Immunosuppression and PSC. Christoph Schramm, Ansgar W. Lohse I. Medizinische Klinik und Poliklinik Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany. Immunosuppression and PSC - background.

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Christoph Schramm, Ansgar W. Lohse I. Medizinische Klinik und Poliklinik

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  1. Immunosuppression and PSC Christoph Schramm, Ansgar W. Lohse I. Medizinische Klinik und Poliklinik Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany

  2. Immunosuppression and PSC - background • Up to 10 % of PSC patients have overlapping features with autoimmune hepatitis (secondary AIH) • Patients with features of autoimmune hepatitis benefit from immunosuppressive treatment • A potential benefit of immunosuppression on early stages of PSC is unknown

  3. Hypothesis • Patients with an inflammatory type of PSC / secondary autoimmune hepatitis benefit from immunosuppression with prednisolone/azathioprine

  4. Study Group project • Retrospective study: • Collect data on patients with PSC who received immunosuppression not related to IBD • Compare long term survival/Ltx to matched control population without immunosuppression • Prospective study: • Define criteria for immunosuppression in PSC, e.g. ALT > 3x ULN, IgG > 1,2x ULN, histology with mHAI > 6, Scheuer > 2 (portal/periportal activity) • Prospectively collect data

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