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Smallpox

Smallpox. Divya Raj. History. 3,000 years ago- Africa, Asia, Europe New World- 1400s-1500s. Variola (major/ minor) Orthopoxvirus, Poxiviridae Brick Linear double-stranded DNA. Smallpox Types. Variola Vaccinia Cowpox Monkeypox. Transmission. Airborne Bodily Fluids Contagious.

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Smallpox

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  1. Smallpox Divya Raj

  2. History • 3,000 years ago- Africa, Asia, Europe • New World- 1400s-1500s

  3. Variola (major/ minor) • Orthopoxvirus, Poxiviridae • Brick • Linear double-stranded DNA

  4. Smallpox Types • Variola • Vaccinia • Cowpox • Monkeypox

  5. Transmission • Airborne • Bodily Fluids • Contagious

  6. Symptoms • Fever • Malaise • Headache • Fatigue • Back Pain • Vomiting, Diarrhea • Rash- Spots, Blisters

  7. Vs. Chickenpox • Severity- Superficial • Location- Trunk • Type- Stage of lesions • Timing- Contagiousness

  8. 4 Types • Ordinary- 90%, unvaccinated • Modified- vaccinated • Malignant- 5-10%, children • Hemorrhagic- 2%, adults

  9. Prognosis • 30% overall • 50-75% ordinary- confluent • 25-30% ordinary- semi-confluent • 90%- Flat • 100%- Hemorrhagic • 1%- Minor

  10. Complications • Scars- 65-85% • Blindness- 2-5%

  11. Treatment • None • Supportive • Inoculation/ Variolation

  12. Vaccine • Edward Jenner • 1796 • Cowpox • Side Effects

  13. Eradication • 1979 • Atlanta, Koltsovo • Destruction

  14. Biological warfare • Lack of vaccination

  15. References • http://www.pbs.org/wgbh/rxforsurvival/series/video/index.html • http://www.pbs.org/wgbh/rxforsurvival/series/diseases/smallpox.html • http://www.who.int/mediacentre/factsheets/smallpox/en/ • http://www.bt.cdc.gov/agent/smallpox/index.asp • http://en.wikipedia.org/wiki/Smallpox • http://www.nlm.nih.gov/exhibition/smallpox/sp_threat.html • http://www.mayoclinic.com/health/smallpox/DS00424/DSECTION=symptoms • http://www.eduplace.com/science/hmsc/6/a/cricket/cktcontent_6a22.shtml

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