1 / 9

Sofosbuvir in HCV Genotype 2, 3 (PEG not an Option) POSITRON

Phase 3. Interferon Intolerant, Unwilling, or Ineligible. Sofosbuvir in HCV Genotype 2, 3 (PEG not an Option) POSITRON. *Note: Published in tandem with FUSION Trial (GT 2,3 and prior failure with PEG). Jacobson I, et al. N Engl J Med. 2013;368:1867-77.

nedaa
Download Presentation

Sofosbuvir in HCV Genotype 2, 3 (PEG not an Option) POSITRON

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Phase 3 Interferon Intolerant, Unwilling, or Ineligible Sofosbuvir in HCV Genotype 2, 3 (PEG not an Option)POSITRON *Note: Published in tandem with FUSION Trial (GT 2,3 and prior failure with PEG) Jacobson I, et al. N Engl J Med. 2013;368:1867-77.

  2. Sofosbuvir + Ribavirin for HCV GT 2 or 3 (PEG not an option)POSITRON Trial: Design Source: Jacobson I,et al. N Engl J Med. 2013;368:1867-77.

  3. Sofosbuvir + Ribavirin for HCV GT 2 or 3 (PEG not an option)POSITRON Trial: Design 0 12 24 Week Sofosbuvir+ RBV 12 weeks N =207 SVR12 Placebo12 weeks N =71 SVR12 Drug DosingSofosbuvir: 400 mg once dailyWeight-Based Ribavirin (in 2 divided doses): 1000 mg/day if < 75kg or 1200 mg/day if ≥ 75kg Source: Jacobson I, et al. N Engl J Med. 2013;368:1867-77.

  4. Sofosbuvir + Ribavirin for HCV GT 2 or 3 (PEG not an option)POSITRON Trial: Reasons for Interferon Ineligibility Source: Jacobson I, et al. N Engl J Med. 2013;368:1867-77.

  5. Sofosbuvir for HCV Infection GT 2,3 (PEG not an option)POSITRON Study: Results POSITRON: Patients on SOF + RBV with HCV RNA <25 IU/ml by Study Timepoint 202/204 202/202 161/207 Placebo arm: 0% for each timepointAbbreviations: SOF = sofosbuvir; RBV = ribavirin Source: Jacobson I, et al. N Engl J Med. 2013;368:1867-77.

  6. Sofosbuvir + Ribavirin for HCV GT 2,3 (PEG not an option)POSITRON Study: Results POSITRON: SVR12 by HCV Genotype 101/109 60/98 Placebo arm: 0% for each timepoint Source: Jacobson I, et al. N Engl J Med. 2013;368:1867-77.

  7. Sofosbuvir + Ribavirin for HCV GT 2,3 (PEG not an option)POSITRON Study: Results POSITRON: SVR12 by Liver Disease 142/176 19/31 Placebo arm: 0% for each timepoint Source: Jacobson I, et al. N Engl J Med. 2013;368:1867-77.

  8. Sofosbuvir + Ribavirin for HCV GT 2,3 (PEG not an option)POSITRON Trial: Conclusions Source: Jacobson I, et al. N Engl J Med. 2013;368:1867-77.

  9. This slide deck is from the University of Washington’s Hepatitis C Online and Hepatitis Web Study projects. Hepatitis C Onlinewww.hepatitisc.uw.edu Hepatitis Web Studyhttp://depts.washington.edu/hepstudy/ Funded by a grant from the Centers for Disease Control and Prevention.

More Related