Pro Flora Oral Health Chewables

1. TM Pro Flora Oral Health Chewables

2. Include eukaryotic fungi, protists, yeasts, bacteria • 3-5 lbs of bacteria (3 trillion microorganisms) • 500-1000 distinct species • Sites of colonization: skin, mucous membranes, gastrointestinal tract, mouth, nose, pharynx, reproductive organs Normal Flora in Humans To these bacteria strains, your body is a resource. Bacteria strains fight for survival amongst each other as they compete for space and nutrients. We support our body the most by having a higher population of healthy bacteria (probiotics). When our level of healthy bacteria is low, bad bacteria, such as Streptococcus mutans, are allowed to flourish.

3. Microbial Population

4. Positive Negative Functions of Human Flora • Immune support • Production of antimicrobials to kill pathogenic bacteria • Synthesis of micronutrients • Digestion of carbohydrates • Maintenance of mucosal health • Reduce inflammation • Maintaining pH • Strep throat • Meningitis • Diarrhea • Cavities, gingivitis • Yeast infections (thrush, candidiasis, vaginal) • Sinusitis

5. Oral Microbiology

6. Healthy bacteria that have life supporting functions. Common probiotics: L. acidophilus, L. rhamnosus, L. paracasei, L. reuteri, S. salivarius Probiotics • Supplementation may support: • Resistance to upper respiratory infections • Reduced sx of IBS and IBD • Gastrointestinal regularity • Weight management • Digestive function • Dental and oral health

7. S. salivarius BLIS K12™is a probiotic strain that lives inside the human mouth. • Research shows that individuals with a naturally higher population of S. salivarius: • Have less dental caries • Are less prone to oral health issues • Have fewer upper respiratory infections S. Salivarius BLIS K12™ This may explain why some individuals who take care of their oral health still experience cavities. While other patients never have dental issues, regardless of poor dietary and lifestyle choices!

8. S. salivarius BLIS K12™ reduces proliferation of bad bacteria by competing for space and nutrients within the oral cavity • S. salivarius BLIS K12™ also produces powerful antimicrobials (Salivaricin A and B) that actually kill pathogenic bacteria • This extra antibacterial punch is what gives • S. salivarius BLIS K12™its powerful probiotic properties How does S. Salivariuswork?

9. BOTH ADULTS AND CHILDREN: S. salivarius BLIS K12™ has also been shown to: • Prevent adhesion of pathogenic oral bacteria • Minimize recurrence of sore throat infections* • Support overall immunity • Reduce bad breath • *Di Pierro F, et al. Clinical evaluation of the oral probiotic Streptococcus salivarius K12 in the prevention of recurrent pharyngitis and/or tonsillitis caused by Streptococcus pyogenes in adults. Expert Opin Biol Ther. 2013 Mar;13(3):339-43. Recent Clinical Research • CHILDREN: S. salivarius BLIS K12™ in Pro Flora Oral Health Chewables was shown in recent clinical trials to: • Minimize the recurrence of common childhood ear infections by 40% • Minimize the recurrence of common childhood throat infections, including strep throat, by 90% • Di Pierro F, et al. Preliminary pediatric clinical evaluation of the oral probiotic Streptococcus salivarius K12 in preventing recurrent pharyngitis and/or tonsillitis caused by Streptococcus pyogenes and recurrent acute otitis media. Int J Gen Med. 2012;5:991-7. TRAVELERS: Germs which enter the body through the nose and mouth are a common cause of concern for travelers. The S. salivarius BLIS K12™ in Pro Flora Oral Health Chewables contain the naturally occurring beneficial bacteria which have been shown to support and boost the throat's natural immune defense system. *These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

10. Dental Caries/Strep mutans Inhibition • A number of recent studies has demonstrated the ability of L.reuteri to inhibit the growth of Streptococcus mutans through a variety of delivery systems. • Consumption of yogurt containing L. reuteri resulted in a significant growth inhibition of Streptococcus mutans. • Koll R, et al. Characterization of oral lactobacilli as potential probiotics for oral health. Oral Micro and Immun. 2008 April; 23(2): 139-147. Recent Clinical Research • Research conducted by the Center of Microbial Disease and Immunity research found that S. salivarius may switch on genes that stimulate epithelial repair and regeneration • In children with recurrent acute otitis media, S. salivarius was shown to have protective effects against the pathogens which cause acute otitis media

11. Contains 1 billion CFUs of S. salivarius BLIS K12™, a 333% increase from the original formula!** ** 2 billion at time of manufacture Pro Flora Oral Health Chewables

12. Pro Flora Oral Health Chewables • Benefits of Pro Flora Oral Health Chewables: • Contains 1 billion CFUs of S. salivarius BLIS K12™, an oral probiotic that helps support oral, throat, and upper respiratory health* • Also contains a blend of beneficial Lactobacilli strains that further support oral health and immune system function* • May reduce infections of the upper respiratory system* • Promotes healthy teeth and gums* • Great-tasting, strawberry-flavored tablet for both children and adults *These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

13. Each chewable contains 3 billion organisms: • S. salivarius BLIS K12™ (1 billion) • Proprietary blend of: • L. paracasei • L. acidophilus • L. plantarum, • L. reuteri • L. rhamnosus • L. salivarius Pro Flora Oral Health Chewables To order call BioGenesis at (866) 272-0500 • Item #204