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“Stemming Vision Loss Using Stem Cells – Seeing is Believing” Prof Pete Coffey

“Stemming Vision Loss Using Stem Cells – Seeing is Believing” Prof Pete Coffey Head of Ocular Biology & Therapeutics UCL Institute of Ophthalmology, London. What visually is it like to have AMD?. Self diagnosis using the Amsler Chart. What an AMD patient sees.

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“Stemming Vision Loss Using Stem Cells – Seeing is Believing” Prof Pete Coffey

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  1. “Stemming Vision Loss Using Stem Cells – Seeing is Believing” Prof Pete Coffey Head of Ocular Biology & Therapeutics UCL Institute of Ophthalmology, London

  2. What visually is it like to have AMD? Self diagnosis using the Amsler Chart What an AMD patient sees. • Above is the type of visual problem experienced by an AMD sufferer.

  3. Optic nerve head Macula Normal Eye Dry AMD Wet AMD Age-related Macular Degeneration

  4. What are we repopulating?

  5. RPE – AMD (Geographic) Macular Dystrophy Photoreceptors – RP Rods or Cones Vasculature – Diabetic Retinopathy Ganglion Cells – Glaucoma What are we repopulating AND WHY?

  6. Replace the faulty RPE Autologous RPE Transplantation

  7. RPE Transplantation

  8. Outcome – the graft 1.5 mm Pre-op Post-op

  9. Replace the faulty RPE Stem Cells

  10. Stem Cell Source and Potential IVF Fetus Sourcing of Stem Cells Islet Neural In vitro culture Haematopoietic ES Cartilage Blastocyst Islet Cells Cartilage Neurons

  11. Where Are Early Stem Cells Found? 5 days of development • Who did it first? • In 1998, U. Wisconsin research team isolates stem cells from IVF-blastocysts

  12. Courtesy of Dr George Nikas

  13. Differentiated HESC-derived RPE HESC-derived RPE 17 year old human

  14. Routes to increasing efficiency of photoreceptor production (1) Photoreceptors RPE

  15. How do you deliver the cells? The problem of an aged Bruchs membrane Cell suspensions may fail to attach to Bruchs membrane Solution: manufacture an artificial membrane

  16. Artificial RPE - Choroid

  17. RPE Transplantation

  18. Large Patient Surgical Procedures

  19. RPE Transplantation

  20. RPE – AMD (Geographic) Macular Dystrophy Photoreceptors – RP Rods or Cones What are we repopulating AND WHY?

  21. Patch plus HESCRPE Pig Retina INL PR INL GC GC Patch alone

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