1 / 8

Don Seto, Ph. D. Associate Professor Bioinformatics and Computational Biology Program

“Exploration of adenovirus diversity with genomics and bioinformatics; development of bioinformatics tools; and applications to real world problems”. Don Seto, Ph. D. Associate Professor Bioinformatics and Computational Biology Program School of Computational Sciences George Mason University.

neona
Download Presentation

Don Seto, Ph. D. Associate Professor Bioinformatics and Computational Biology Program

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. “Exploration of adenovirus diversity with genomics and bioinformatics; development of bioinformatics tools; and applications to real world problems” Don Seto, Ph. D.Associate ProfessorBioinformatics and Computational Biology Program School of Computational SciencesGeorge Mason University

  2. Host Response Gene Expression Profiles Respiratory Pathogen Microarray (RPM) Z-chip from concept to delivery (Operational from 07 Jun 2003) Common and biowarfare agents Iterative design and process Delivery, evaluation, and validation Common Pathogens Human Host Genome Pathogen Chip EOS Pathogen Pie Anthrax Over 30,000 human genes per test Up to 500,000 diagnostic tests per chip West Nile Biowarfare Pathogens SARS Smallpox Anthrax Plague Tularemia Ebola Virus Lassa Fever Real Data Healthy Sick (FRI) Advanced Molecular Diagnostics Operations and Deliverables

  3. Genome data mining: Pathogen sequence signatures From genome data: To signatures data: TAG TAA TGA PROMOTER ATG Applied versus Basic

  4. Genome data mining:Regulatory and other non-coding features Basic versus Applied

  5. Comparative gene/protein analysis and adenovirus evolution: HAdV-E from B and/or C Questions…….. Gruber et al., ‘93

  6. In progress (Nov. 04)…….. • HAdV-1: JGenVirol • HAdV-4: JVirol • HAdV-7: Virol • Vaccines: JCM (in press) • Field strains: ? • B1/B2 • HAdV-6 • Phylogeny • ---->HAdV-40: ?

  7. Distribution of HAdV serotypes causing ARD

  8. Multiple sequence alignments of ITRs by eye

More Related