80 likes | 367 Views
“Exploration of adenovirus diversity with genomics and bioinformatics; development of bioinformatics tools; and applications to real world problems”. Don Seto, Ph. D. Associate Professor Bioinformatics and Computational Biology Program School of Computational Sciences George Mason University.
E N D
“Exploration of adenovirus diversity with genomics and bioinformatics; development of bioinformatics tools; and applications to real world problems” Don Seto, Ph. D.Associate ProfessorBioinformatics and Computational Biology Program School of Computational SciencesGeorge Mason University
Host Response Gene Expression Profiles Respiratory Pathogen Microarray (RPM) Z-chip from concept to delivery (Operational from 07 Jun 2003) Common and biowarfare agents Iterative design and process Delivery, evaluation, and validation Common Pathogens Human Host Genome Pathogen Chip EOS Pathogen Pie Anthrax Over 30,000 human genes per test Up to 500,000 diagnostic tests per chip West Nile Biowarfare Pathogens SARS Smallpox Anthrax Plague Tularemia Ebola Virus Lassa Fever Real Data Healthy Sick (FRI) Advanced Molecular Diagnostics Operations and Deliverables
Genome data mining: Pathogen sequence signatures From genome data: To signatures data: TAG TAA TGA PROMOTER ATG Applied versus Basic
Genome data mining:Regulatory and other non-coding features Basic versus Applied
Comparative gene/protein analysis and adenovirus evolution: HAdV-E from B and/or C Questions…….. Gruber et al., ‘93
In progress (Nov. 04)…….. • HAdV-1: JGenVirol • HAdV-4: JVirol • HAdV-7: Virol • Vaccines: JCM (in press) • Field strains: ? • B1/B2 • HAdV-6 • Phylogeny • ---->HAdV-40: ?