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Drug abuse & dependence

Drug abuse & dependence. 署立新竹醫院神經科 葉伯壽. Drug dependence. Psychological dependence Physical dependence Compulsive drug abuse Drug addiction. Factors to drug dependence. Psychological factors Neurochemical and neuropharmacological factors Environmental factors.

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Drug abuse & dependence

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  1. Drug abuse & dependence • 署立新竹醫院神經科 葉伯壽

  2. Drug dependence • Psychological dependence • Physical dependence • Compulsive drug abuse • Drug addiction

  3. Factors to drug dependence • Psychological factors • Neurochemical and neuropharmacological factors • Environmental factors

  4. Common abuse chemicals • Opiates (narcotic analgesics) • CNS stimulants- cocaine & amphetamine • Cannabis • Lysergic acid diethylamide (LSD) • Alcohol • Hypnotics • Nicotine (tobacco)

  5. FlowerErythroxylon Coca --cocaine

  6. Cocaine drink

  7. Cocaine effect

  8. Cocaine—dopamine re-uptake blockage

  9. Positron Emission Tomography (PET)

  10. PET-- Cocaine 1-2 Min 3-4 5-6 6-7 7-8 8-9 9-10 10-20 20-30

  11. PET: cocaine withdraw Normal Cocaine Abuser (10 day) Cocaine Abuser (100 day)

  12. Amphetamine-type stimulants

  13. 安非他命 • 1887 德 Edeleano 合成 • 1914 Merk—MDMA (搖頭丸ecstasy)抑制食慾 • 1920 KK.Chen (Lilly)—麻黄素(ephedrine) • 1930 SKF—含安非他命的Benzedrine • 二次世界大戰,德、英、美軍及日本軍民濫用。 • 1950-60 MDMA 用於輔助心理治療。 • 1960年代,美嬉皮族—LSD+Amphetamine • 1986 DrugEnforcement Administration列為禁藥 • 90年代,冰(Ice)

  14. Long-term Consequences Amphetamine

  15. Drug abuse

  16. Cannabis, Marijuana大麻

  17. Localization of THC binding site

  18. THC in accumbens nucleus

  19. Reward system via dopamine

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