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Jayanand Manjhi, PhD; Suneel Kumar, MSc; Jitendra Behari, PhD; Rashmi Mathur, PhD

Effect of extremely low frequency magnetic field in prevention of spinal cord injury-induced osteoporosis. Jayanand Manjhi, PhD; Suneel Kumar, MSc; Jitendra Behari, PhD; Rashmi Mathur, PhD. Aim

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Jayanand Manjhi, PhD; Suneel Kumar, MSc; Jitendra Behari, PhD; Rashmi Mathur, PhD

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  1. Effect of extremely low frequency magnetic field in prevention of spinal cord injury-induced osteoporosis Jayanand Manjhi, PhD; Suneel Kumar, MSc; Jitendra Behari, PhD; Rashmi Mathur, PhD

  2. Aim • Investigate effect of extremely low frequency (ELF) magnetic field (MF) on spinal cord injury (SCI)-induced osteoporosis in rats. • Relevance • SCI-induced osteoporosis is most rapid and severe form of osteoporosis. • Pulsed electromagnetic field therapy is reported to promote peripheral nerve regeneration, osteogenesis, and SCI recovery.

  3. Method • Adult Wistar rats were equally divided into 3 groups: • SCI and SCI+MF: complete spinal cord transection. • Sham: laminectomy only. • 1 d post-SCI: exposed to ELF-MF or sham exposed. • Basso, Beattie, and Bresnahan (BBB) score was recorded weekly. • All rats were sacrificed 8 wk post-SCI: • Tibias and femurs were isolated for bone mineral content (BMC), bone mineral density (BMD), and biochemical status analyses.

  4. Results • BBB score decreased post-SCI, which partially recovered after ELF-MF. • SCI rats (vs sham): • Statistically significant decrease in BMC, calcium, phosphorus, carbon, BMD, and biochemical level, which attenuated in SCI+MF rats except carbon content. • Electron microscopic study revealed enhanced microstructural composition and compactness in cortical and trabecular parts of treated bones.

  5. Example of spinal cord 8 wk post-SCI in SCI and SCI+MF rats. Note areas of continuity in spinal cord and smaller cavities vis-à-vis degeneration of neurons (arrow mark) in SCI+MF vs SCI group.

  6. Conclusion • Results suggest that chronic ELF-MF exposure to SCI rats effectively attenuates SCI-induced osteoporosis.

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