E N D
Biomed BCT Bioterroism
The first well-documented use of smallpox as a biological weapon was by British troops in the French and Indian Wars. In 1763 two blankets and a handkerchief laced with smallpox were given to the Native Americans as gifts killing as many as half of the population of the infected tribes. Bioterroism
Bioterroism: violent acts, dangerous to human life that appear to be intended: • To intimidate or coerce a civilian population • To influence the policy of a government by intimidation or coercion • To affect the conduct of a government by assassination or kidnapping Bioterroism
Biological weapons are: • Living microorganisms such as bacteria, viruses, fungi, that can kill or incapacitate Bioterroism
Classification • The Centers for Disease Control and Prevention (CDC) categorize biological agents according to the risk they pose to the public. Bioterroism
Category A : • Those that pose the highest risk (can be easily disseminated and result in high mortality). • Include bacteria and viruses that cause diseases such as: • anthrax, • botulism, • plague, • tularemia, • smallpox, and • viral hemorrhagic fever (such as hantavirus and ebola). Bioterroism
Category B: • pose a moderate risk to the public • can be spread with some ease • can cause a moderate degree of illness • death rates due to these diseases are usually low Bioterroism
Other Types of Agents • In addition to biological agents, chemical or radioactive agents may also be used as weapons of bioterrorism. Bioterroism
Chemical Agents • The CDC classifies chemical agents according to their target activity on the skin, in the lungs, in the gastrointestinal tract, and in the nervous system Bioterroism
Radioactive agents • Colorless, odorless, and invisible to the eye. Bioterroism
Contamination of food, water, or objects may disable or kill humans and animals and be difficult to trace. Bioterroism
Symptoms of Radiation Exposure • Symptoms of radiation exposure may include: • nausea, vomiting, diarrhea and, depending on the extent of the exposure, bleeding gums, nosebleeds, bruising, and hair loss. • http://www.standeyo.com/News_Files/NBC/radiation.human.body.html Bioterroism
The Pain of Exposure • Exposure can be through ingestion, inhalation, or contamination of an open wound. Bioterroism
Response to bioterroism agents: • New Report: North Carolina Earns Grade of 10 out of 10 on Disaster Preparedness Bioterroism
Internal reporting requirements (within a facility) • Infectious control personnel • Epidemiologist (local and state) • Administration (health care facility and health department) • Office of public affairs in the health facility Bioterroism
External contacts (outside of facility) • Local health department • State health department • FBI • CDC • Local police • EMS Bioterroism
Examine the containment of bioterroism agents • Agents • Containment of agents Bioterroism
ANATHRAX PLAGUE BACTERIAL Bioterroism
AnthraxAcute infectious disease caused by bacillus anthracis. Bioterroism
ANTHRAX • Modes of transmission: • Inhalation of spores • Skin contact • Ingestion of contaminated food • Incubation period: • Pulmonary: 2-60 days • Cutaneous: 1-7 days • Gastrointestinal: 1-7 days • Transmission: • Anthrax is not airborne person to person. Direct contact with infectious skin lesions can transmit infection. • Prevention: • Vaccine available-limited quantities. Bioterroism
Infections in humans: • Skin contact – cutaneous, ingestion-gastrointestinal, inhalation-pumonary • Person-to-person transmission of inhalation disease does not occur. * • *direct exposure to vesicle secretions of cutaneous anthrax can result in a secondary infection. Bioterroism
Abdominal pain, nausea, vomiting, fever Bloody diarrhea, hematemesis Positive culture after 2-3 days Prognosis: If progression to toxemia and sepsis, prognosis is poor. Gastrointestinal signs and symptoms: Bioterroism
Local skin involvement with direct contact Commonly seen on head, forearms, or hands Localized itching followed by popular lesion that turns vescular within 2-6 days – develops into depressed black eschar Prognosis: Good if treated with antibiotics. Cutaneous signs and symptoms: Bioterroism
S/S Flu-like symptoms that may briefly improve two to four days after initial symptoms Abrupt onset of respiratory failure Hemodynamic collapse Thoracic edema Widened mediastinum on xray Positive blood culture in 2-3 days of illness Prognosis: Good if treated early. Increased mortality rate if treated after respiratory onset. Pulmonary signs and symptoms: Bioterroism
Anthrax Bioterroism
What bioterrorism agent was sent through the mail to federal agencies in Washington D.C. in October, 2001? • a] Cholera • b] Anthrax • c] Malaria Bioterroism
Plague is an acute bacterial disease caused by yersinia pestis. Signs and Symptoms: Fever Cough Chest pain Hemoptysis Watery sputum Bronchopneumonia on x-ray Plague Bioterroism
Plague • Bubonic plague : enlarged, tender lymph nodes, fever, chills and prostration • Septicemic plague: fever, chills, prostration, abdominal pain, shock and bleeding into skin and other organs • Pneumonic plague: fever, chills, cough and difficulty breathing; rapid shock and death if not treated early Bioterroism
TRANSMISSION • Flea-borne, from infected rodents to humans • Direct contact with infected tissues or fluids from handling sick or dead animals • Respiratory droplets from cats and humans with pneumonic plague Bioterroism
Mode of Transmission: • Plague normally transmitted from an infected flea • Can be aerosol-probable use in bio terrorism • Can be transmitted person to person • Incubation period: • Flea bite – 2-8 days • Aerosol – 1-3 days • Prognosis: Good if treated with antibiotics early. Bioterroism
All of the following are ways that the plague can be transmitted except: • A) an infected flea • B) aerosol • C) food and or water Bioterroism
http://www.citypaper.com/news/story.asp?id=7379 Plague satisfies all three requirements. A historic terror, the disease decimated one-third of Europe's population in the 14th century. Although initial symptoms of plague are similar to a cold (swollen glands, fever, chills, headache), if the disease progresses, the bacteria can cause internal hemorrhaging and tissue necrosis. The dead tissues eventually become gangrenous, causing the victim to turn black--hence the disease's macabre nickname, "Black Death." The Hot SeatDr. Thomas Butler Had Very Good Reasons for Carrying Bubonic Plague Aboard Passenger Flights--But That Didn't Stop The U.S. Government From Ruining his Life Bioterroism
A) Pneumonic B) Bubonic C) Septicemic The Wyoming Department of Health is investigating how a Boy Scout who visited northwest Wyoming became infected with bubonic plague. Which type of plague is characterized by enlarge, tender lymph nodes Bioterroism
VIRAL • SMALLPOX Bioterroism
Smallpox • Smallpox is an acute viral illness caused by the variola virus. • Mode of transmission: • Airborne: droplets • direct contact with infected bodily fluids or contaminated objects such as bedding or clothing. • Signs and symptoms: • Flu like symptoms-fever, myalgia • Skin lesions appear quickly progressing from macules to papules to vesicles • Rash scabs over in 1-2 weeks • Rash occurs in all areas at once, not in crops Bioterroism
Incubation period: • From 7 to17 days, average is 12 days • Contagious when the rash is apparent and remains infectious until scabs separate (approx. 3 weeks) • Prognosis: • Vaccine available and effective post-exposure • Passive immunization is also available in the form of vaccina- immune-globulin (VZIG) Bioterroism
Smallpox has a high mortality rate. • Smallpox (also called variola) is the only disease that has been completely wiped out throughout the world. • Smallpox is also potentially one of the most devastating biological weapons ever conceived. • The (WHO) officially declared smallpox eradicated in 1980. Bioterroism
Current locations of smallpox virus: Only two laboratories in the world are known to house smallpox virus: the (CDC) in Atlanta, Georgia, and the State Research Center of Virology and Biotechnology in Koltsovo, Russia. Bioterroism
Why were the British able to infect the American Indians with smallpox Bioterroism
BOTULISM RICIN TOXINS Bioterrorism
Botulism • Potent neurotoxin caused by an anaerobic bacillus- colstridium botulinum. • Transmission: • Contaminated food • Inhalation Bioterroism