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Lecture 7 Gene Structure and Transposable Elements Gene structure Gene families

Lecture 7 Gene Structure and Transposable Elements Gene structure Gene families Repetitive DNA including transposons Organelle genomes Reading: Chapter 10. Molecular Biology syllabus web site. Gene Structure. Gene Families. -tissue-specific and temporal-specific expression

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Lecture 7 Gene Structure and Transposable Elements Gene structure Gene families

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  1. Lecture 7 Gene Structure and Transposable Elements Gene structure Gene families Repetitive DNA including transposons Organelle genomes Reading: Chapter 10 Molecular Biology syllabus web site

  2. Gene Structure

  3. Gene Families -tissue-specific and temporal-specific expression -diverging activities or localization

  4. DNA Classes

  5. Reassociation experiments reveal three major fractions of eukaryotic DNA • Single copy DNA (50-60%) • Moderately-repeated/ intermediate-repeat DNA (25-40%); includes mobile DNA elements • Simple-sequence DNA (10-15%)

  6. Human metaphase chromosomes: in situ hybridization with fluorescent-labelled “simple sequence” DNA probe

  7. Probe ‘b’ Human DNA fingerprints DNA probed with 3 different microsatellite DNA probes a,b,c show characteristic patterns of individuals.

  8. Mutable phenotypes caused by transposable elements nonmutable mutable

  9. Transposable Elements

  10. Transposable element excision results in target site duplication or other DNA sequence changes

  11. Chromatin Structure

  12. Nucleosomes DNA

  13. DNA

  14. Chromatin structure changes during differentiation of cells Differentiated red blood cells at 14 days Cultured undifferentiated MSB cells

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