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Seed Project:

Seed Project: Engineering lipid membrane conformations using proteins involved in transport within cells Seth Raden , Brandeis University, DMR 0820492.

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Seed Project:

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  1. Seed Project: Engineering lipid membrane conformations using proteins involved in transport within cells Seth Raden, Brandeis University, DMR 0820492 Biological membranes are pinched, bent, and deformed into highly specialized shapes that are tailored for compartmentalizing biochemical processes within cells. We are exploring the physical basis for how a cohort of curved membrane-deforming proteins called F-BAR proteins act to sculpt membranes. We have devised biochemical and cellular assays to generate membrane tubules of specific shape, lipid composition, and stiffness. These assays allow us to use a combination of experiments and theory to explore how tweaking the membrane deformation machinery modulates membrane organization and structure. We have found that apparently structurally similar membrane deforming proteins produce tubules with very different properties, and we are exploring whether the basis for these differences is in properties of protein interaction with the membrane, local changes in membrane composition, or the effects of protein assembly into higher order structures. Synd Nwk In vitro deformation of giant unilamellar vesicles Membrane deformation in cultured cells Electron micrographs of cellular (left) and in vitro (right) effects of Nwk

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