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Chapter 11

Chapter 11. Organization and Rearrangement of BCR and TCR Genes. Overview of B-cell development. Organization of Ig gene segments in the mouse. V-variable D-diversity J-joining C-constant L-leader. V gene. 聚腺苷酸形成. RNA 拼接.

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Chapter 11

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  1. Chapter 11 Organization and Rearrangement of BCR and TCR Genes

  2. Overview of B-cell development

  3. Organization of Ig gene segments in the mouse V-variable D-diversity J-joining C-constant L-leader V gene

  4. 聚腺苷酸形成 RNA拼接 Kappa light-chain gene rearrangement and RNA processing

  5. Heavy-chain gene rearrangement and RNA processing

  6. Expression of secreted and membrane form of the heavy chain

  7. Allelic Exclusion

  8. Diversity of BCR Combinatorial diversity (2.5x108) Junctional diversity Somatic hypermutation Total: 1014

  9. TCR Diversity

  10. Structure of TCR Hypervariable region(1-4) Disulfide bridges

  11. Germ-line organization of the mouse TCR α,β,γ and δ-chain gene segments

  12. Example of gene rearrangements that yield a functional gene encoding the αβ TCR

  13. Diversity of TCR 1016

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