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J. van Engelen and C. Delmaar | September 4, 2006

J. van Engelen and C. Delmaar | September 4, 2006. Use of Computer Models for consumer exposure assessment. ISEA/ISEE Meeting 2006, Paris. Large Variety of Consumer Products. Consumer exposure to chemicals. Scope & purpose of exposure assessment. Scenario Products Exposure routes

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J. van Engelen and C. Delmaar | September 4, 2006

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  1. J. van Engelen and C. Delmaar | September 4, 2006 Use of Computer Models for consumer exposure assessment ISEA/ISEE Meeting 2006, Paris

  2. Large Variety of Consumer Products Jacqueline van Engelen and Christaan Delmaar

  3. Consumer exposure to chemicals • Scope & purpose of exposure assessment Scenario • Products • Exposure routes • End points • Exposed population/groups Chemical Exposure modelling Exposure measurement Assessmentof the risk Jacqueline van Engelen and Christaan Delmaar

  4. Modelling or measurements ? Advantage of Measurements: • Direct measurement of exposure Advantage of Modelling: • No exposure data available • Not resource intensive • Possibility to study impact of changes in product properties or exposure factors Combination: • Model validation • Determination of input parameters • Models can be useful for interpretation of measurements • Models can be used to extrapolate experimental data to alternative scenarios Jacqueline van Engelen and Christaan Delmaar

  5. Modelling consumer exposure to chemicals in consumer products: ConsExpo Set of models describing various exposure processes • Multi-route • inhalation • dermal • oral • Tiered Approach • first order screening models • more detailed models • population exposure calculation tools (limited) Jacqueline van Engelen and Christaan Delmaar

  6. ConsExpo models Inhalation • Vapours • Sprays (particulate) Dermal • Direct dermal contact with product Oral • Direct oral contact with product • Migration from packaging material to food • External and internal (uptake) exposure models Jacqueline van Engelen and Christaan Delmaar

  7. RIVM factsheets/ ConsExpo database • Classification of product groups according to exposure characteristics • Enhance transparency and standardization • Provide selection of the ConsExpo models for a given scenario • Provide default exposure parameters for each class • Defaults serve as starting point exposure assessment • Not aimed at specific chemicals • All values are available in a product database Jacqueline van Engelen and Christaan Delmaar

  8. Jacqueline van Engelen and Christaan Delmaar

  9. Needs for the near future (ConsExpo) • Model validation • Extension of databases improvement/extension of models (e.g. release from solids) • Improvement of capabilities for probabilistic modelling • Aggregate exposure • Communication with other data libraries • … Jacqueline van Engelen and Christaan Delmaar

  10. Focus for the near future (general) • Population exposure (probabilistic modelling) • Generation of experimental data to be used as input parameters Jacqueline van Engelen and Christaan Delmaar

  11. Exposure Scenarios (ES) and REACH The set of conditions that describe how the substance is manufactured or used during its life-cycle and how the manufacturer or importer controls, or recommends downstream users to control, exposures of humans and the environment. These exposure scenarios may cover one specific process or use or several processes or uses as appropriate The REACH exposure scenario prescribes appropriate risk management measures (RMMs) that serve to effectively manage health, environmental and safety risks from the chemical during its entire life-cycle Integration! Jacqueline van Engelen and Christaan Delmaar

  12. Focus for the near future (REACH related) • Level of detail (depends on scope/problem): need for very broad/specific scenarios (simple/complex algorithms) • Extension of existing exposure data libraries (e.g. ECETOC-TRA/ConsExpo/EIS-ChemRisks-toolbox) • Aggregate exposure • Concept of ES and quantification of RMMs • Exposure from articles (esp. for substances not intended to be released) Jacqueline van Engelen and Christaan Delmaar

  13. Thank you for your attention Jacqueline van Engelen and Christaan Delmaar

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