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Fast Geometric Consensus Approach for Protein Model Quality Assessment

Fast Geometric Consensus Approach for Protein Model Quality Assessment. Jaroslaw Meller, University of Cincinnati College of Medicine Published at Journal of Computational Biology, 2011. Presented by Chao Wang. Motivation & Background. Template selection and Model selection for CASP

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Fast Geometric Consensus Approach for Protein Model Quality Assessment

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  1. Fast Geometric Consensus Approach for Protein Model Quality Assessment Jaroslaw Meller, University of Cincinnati College of Medicine Published at Journal of Computational Biology, 2011 Presented by Chao Wang

  2. Motivation & Background • Template selection and Model selection for CASP • True (individual) MQA and Consensus MQA • F=U-TS • F: Free Energy • U: Internal Energy • T: Temprature • S: Entropy • All happy families are alike but unfortunate families each are not identical. --Leo Tolstoy ``Anna Karenina''

  3. Introduction

  4. Methods • How to define • How to calculate • Data sets

  5. Methods

  6. Data sets

  7. Results

  8. Conclusion • ……

  9. Chao's comments • Chao's perspective: • All methods which not distinguishing templates are not efficient. • CLE rather than SS • D-score is higher complexible on the length of structure • Merge true QA and consensus QA in our SVM • Effect from templates

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