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Heat Stability of Benzodiazepines

Heat Stability of Benzodiazepines. Jason McMullan, MD (Cincinnati) RAMPART Investigators Meeting June 29, 2012. Background. Lorazepam is not heat-stable Diazepam is likely heat-stable Midazolam’s heat-stability is unknown. RAMPART Drug QA. Random HPLC analysis of Pre-deployed medications

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Heat Stability of Benzodiazepines

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  1. Heat Stability of Benzodiazepines Jason McMullan, MD (Cincinnati) RAMPART Investigators Meeting June 29, 2012

  2. Background • Lorazepam is not heat-stable • Diazepam is likely heat-stable • Midazolam’s heat-stability is unknown

  3. RAMPART Drug QA • Random HPLC analysis of • Pre-deployed medications • “Expired” (post-deployed) medications • All sites represented • “Hottest” sites oversampled • MKT calculated from temp files of study box

  4. What about diazepam or potential longer shelf-life?

  5. All 3 benzodiazepines • 120-day exposure with q30-day sampling • Focus on two “hot” sites in hot months • RAMPART study boxes for temperatures

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