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Last Class: 1. transportation at the plasma membrane A. carrier protein, B. channel protein 2. intracellular compartment

Last Class: 1. transportation at the plasma membrane A. carrier protein, B. channel protein 2. intracellular compartments A. nucleus, B. Endoplasmic Reticulum. Intracellular Vesicular Traffic. The endocytic and biosynthetic-secretory pathways. Vesicular transport.

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Last Class: 1. transportation at the plasma membrane A. carrier protein, B. channel protein 2. intracellular compartment

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  1. Last Class: • 1. transportation at the plasma membrane • A. carrier protein, B. channel protein • 2. intracellular compartments • A. nucleus, B. Endoplasmic Reticulum

  2. Intracellular Vesicular Traffic

  3. The endocytic and biosynthetic-secretory pathways

  4. Vesicular transport

  5. The intracellular compartments of the eucaryotic cell in the biosynthetic-secretory and endocytic pathways

  6. Utilization of different coats in vesicular traffic

  7. Clathrin-coated pits and vesicles

  8. The structure of a clathrin coat

  9. The assembly and disassembly of a clathrin coat

  10. The role of dynamin in pinching off clathrin-coated vesicles from the membrane Shibire mutant in drosophila

  11. A current model of COPII-coated vesicle formation

  12. The postulated role of SNAREs in guiding vesicular transport

  13. The structure of paired snare

  14. A model for how SNARE proteins may concentrate in membrane fusion

  15. Dissociation of SNARE pairs by NSF after a membrane fusion cycle is completed

  16. A postulated role of Rab protein in facilitating the docking of transport vesicles

  17. The entry of enveloped viruses into cells

  18. Transport from the ER through the Golgi apparatus

  19. The recruitment of cargo molecules into ER transport vesicles

  20. Retention of incompletely assembled antibody molecules in the ER

  21. Vesicular tubular clusters

  22. A model for the retrieval of ER resident proteins

  23. The Golgi apparatus

  24. The functional compartmentalization of the Golgi apparatus Notice of multiple steps involving glycosylation

  25. Two possible models explaining the organization of the Golgi apparatus and the transport of proteins from one cisterna to the next

  26. Transport from the trans Golgi nextwork to Lysosomes

  27. Lysosomes Low pH Full of Acid hydrolases

  28. The structure of mannose 6-phosphate on a lysosome enzyme

  29. The transport of newly synthesized lysosomal hydrolases to lysosomes

  30. Transport into the cell from the plasma membrane endocytosis

  31. Phagocytosis by a macrophage Phagocytosis: large particle, >250nm Pinocytosis: fluid, liquid, 100 nm One macrophage and two red blood cells

  32. The formation of clathrin-coated vesicles from the plasma membrane

  33. Caveolae in the plasma membrane of a fibroblast

  34. A low-density lipoprotein (LDL) particle

  35. Normal and mutant LDL receptor

  36. The receptor-mediated endocytosis of LDL

  37. Possible fates for transmembrane receptor proteins that have been endocytosed

  38. Storage of plasma membrane proteins in recycling endosomes

  39. Transcytosis

  40. Sorting of membrane proteins in the endocytic pathway Green: EGF-EGFR Red: transferrin and its receptor

  41. The sequestration of endocytosed proteins into internal membranes of multivesicular bodies

  42. Transport from the trans Golgi network to the cell exterior: exocytosis

  43. The constitutive and regulated secretory pathways

  44. The three best-understood pathways of protein sorting in the trans Golgi network

  45. Exocytosis of secretory vesicles

  46. Electron micrographs of exocytosis in rat mast cells Release of histamine

  47. Exocytosis as a localized responses Beads attachment localized the release

  48. Model of lipid rafts in the trans Golgi network

  49. The formation of synaptic vesicles

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