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Dr Michael Valenzuela School of Psychiatry University of New South Wales

Cognitive Lifestyle. Dr Michael Valenzuela School of Psychiatry University of New South Wales. Dr Michael Valenzuela Senior Research Fellow, University of New South Wales, Sydney Australia. Vel á zquez (1657). Dr Michael Valenzuela School of Psychiatry University of New South Wales.

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Dr Michael Valenzuela School of Psychiatry University of New South Wales

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  1. Cognitive Lifestyle • Dr Michael Valenzuela • School of Psychiatry • University of New South Wales • Dr Michael Valenzuela • Senior Research Fellow, • University of New South Wales, Sydney Australia

  2. Velázquez (1657)

  3. Dr Michael Valenzuela • School of Psychiatry • University of New South Wales Picasso (1957)

  4. Education Mental Leisure Activities Occupational Complexity What is Cognitive Lifestyle?

  5. Education Mental Leisure Activities Occupational Complexity What is Cognitive Lifestyle? Throughout Lifespan!

  6. OR 0.54 Importance of Cognitive Lifestyle Those with more active cognitive lifestyle have almost 50% less risk for dementia

  7. How to Measure Cognitive Lifestyle? • Lifespan approach to measure • Educational activities • Occupational Complexity • Cognitive-loaded leisure activities • During • Young Adulthood (16-30 years) • Mid-Life (31-65 years) • Late Life (>65 years)

  8. Disease Modification Does active cognitive lifestyle protect the brain from developing the disease itself? Active Cognitive Lifestyle Neuroprotection Lowered risk of developing dementia Does active cognitive lifestyle protect nearby brain cells from the effects of disease? Compensation Does active cognitive lifestyle help the brain adapt and reorganise? How could it work?

  9. Components of Cognitive Lifestyle Collaboration with UK Medical Research Council Cognitive Function & Ageing Study (CFAS)

  10. Components of Cognitive Lifestyle Collaboration with UK Medical Research Council Cognitive Function & Ageing Study (CFAS)

  11. Components of Cognitive Lifestyle Collaboration with UK Medical Research Council Cognitive Function & Ageing Study (CFAS)

  12. Components of Cognitive Lifestyle Collaboration with UK Medical Research Council Cognitive Function & Ageing Study (CFAS)

  13. Mechanisms of Cognitive Lifestyle • Mechanism #1: Alzheimer disease modification NO EFFECT! Collaboration with UK Medical Research Council Cognitive Function & Ageing Study (CFAS)

  14. Mechanisms of Cognitive Lifestyle • Mechanism #2: Vascular disease modification Collaboration with UK Medical Research Council Cognitive Function & Ageing Study (CFAS)

  15. Mechanisms of Cognitive Lifestyle • Mechanism #3: Compensation Cognitive Lifestyle Collaboration with UK Medical Research Council Cognitive Function & Ageing Study (CFAS)

  16. Mechanisms of Cognitive Lifestyle • Mechanism #3: Compensation Cognitive Lifestyle Collaboration with UK Medical Research Council Cognitive Function & Ageing Study (CFAS)

  17. Mechanisms of Cognitive Lifestyle • Brain Imaging Confirmation LEQ = X X Memory & Ageing Study

  18. Mechanisms of Cognitive Lifestyle • Brain Imaging Confirmation LEQ = X X Memory & Ageing Study

  19. Micro-vascular disease ♂ Unique compensatory network in those with disease ♀ Mass effect Overview: Benefits of Active Cognitive Lifestyle Neuronal Density Cortical Thickness Normal Memory network

  20. Micro-vascular disease ♂ Unique compensatory network in those with disease ♀ Mass effect Overview: Benefits of Active Cognitive Lifestyle Neuronal Density Cortical Thickness Normal Memory network UNIQUE SCIENTIFIC INFORMATION GAINED BY BRAIN DONATION

  21. So what to do? The Three Keys • Human and rodent studies agree that the most powerful activities will have three key ingredients: • Cognitive Key: learning something new, problem solving, remembering or strategy… must bechallenging • Social Key: with other people. Socializing demands good cognitive and physical activity as well! • Physical Key: some type of physical exercise or skill practice

  22. Implications for Self & Society We should all take up a new hobby, past time or passion in ‘retirement’ which addresses the Three Keys: Mental, Social and Physical activity. Should be mentally challenging, but also fun! Examples…

  23. Implications for Self & Society

  24. Implications for Self & Society

  25. Implications for Self & Society

  26. Cultivation of Virtuous Cycle Active Cognitive, Social & Physical Lifestyle Quality of Life & Happiness Improved Brain Health

  27. More Information • The Science and Art of Neuroplasticity • Healthy Heart, Healthy Brain • Food for Thought • Many other topics about how to keep one’s brain healthy for longer

  28. Many Thanks Mentor - Scientia Professor Perminder Sachdev RNG Students – Marshall Dalton, Andy Turner, Nicola Gates, Chao Suo, Joyce Siette, Andy Turner, Aileen Lowe Collaborators – Carol Brayne, Michael Breakspear, Nicole Kochan, Maria Fiatarone Singh, Henry Brodaty, Wei Wen Funding – NHMRC, Rebecca Cooper Medical Research Foundation, UNSW, ANZ Mason Foundation

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