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Talk Louder So I Can See You

Talk Louder So I Can See You Cross-Modality Sharpening of Visual Cortical Processing through Layer-1-Mediated Inhibition and Disinhibition Leena A. Ibrahim*, Lukas Mesik*, Xu-ying Ji, Qi Fang, Hai-fu Li, Ya-tang Li, Brian Zingg, Li I. Zhang, Huizhong Whit Tao Neuron

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Talk Louder So I Can See You

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  1. Talk Louder So I Can See You Cross-Modality Sharpening of Visual Cortical Processing through Layer-1-Mediated Inhibition and Disinhibition Leena A. Ibrahim*, Lukas Mesik*, Xu-ying Ji, Qi Fang, Hai-fu Li, Ya-tang Li, Brian Zingg, Li I. Zhang, Huizhong Whit Tao Neuron Volume 89, Issue 5, Pages 1031-1045 (March 2016) DOI: 10.1016/j.neuron.2016.01.027

  2. Mouse on a ball – calcium imaging and cell attached recordings (exclude segments when mouse is running)

  3. Sound-induced sharpening of orientation selectivity in L2/3 of V1

  4. Sound-induced sharpening of OS observed using 2p imaging

  5. Where is the input coming from? L5 of auditory cortex projects to L1 of visual cortex

  6. Activation of auditory cortical axons sharpens tuning in L2/3 not L4

  7. Which cells in visual cortex are receiving auditory input? Play sounds and do cell-attached recordings in V1

  8. How do these layer 1 cells respond with auditory stimuli? -Enhanced across all orientations

  9. Sound alone excites these cells Early onset of activity means that L1 can shape L2/3 responses

  10. Inactivation of L1 reduces sound modulation of L2/3 cells

  11. Who are these L1 cells driving in L2/3? (calcium imaging) - VIP cells are suppressed by the sound

  12. Summary • Layer (L)5 neurons in A1 project directly to superficial layers of V1 • Sound sharpens orientation selectivity of V1 L2/L3 pyramidal neurons • V1 L1 neurons, strongly innervated by A1 axons, mediate the sharpening effect • Visual responses of V1 L2/L3 VIP neurons are differentially suppressed by sound

  13. How do these layer 1 cells respond with auditory stimuli? -contrast dependence

  14. Summary of L1 activation results L2/3 L4

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