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Glutathione is an Antioxidant

Glutathione is an Antioxidant. ROOH. Glutathione peroxidase (GSH peroxidase). NADH. Glutathione reductase (GSSG reductase). Glutathione (GSH). Glutathione disulfide (GSSG). Glutathione is a Sulfur Nucleophile Involved in the Metabolism of Foreign Substances.

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Glutathione is an Antioxidant

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  1. Glutathione is an Antioxidant ROOH Glutathione peroxidase (GSH peroxidase) NADH Glutathione reductase (GSSG reductase) Glutathione (GSH) Glutathione disulfide (GSSG)

  2. Glutathione is a Sulfur Nucleophile Involved in the Metabolism of Foreign Substances Glutathione (GSH): glutamic acid-cysteine-glycine tripeptide • Glutathione S-transferases catalyze the conjugation of glutathione with foreign compounds and their metabolites. • Conjugation reduces activity of xenobiotics and allows removal from body by increases polarity and water solubility.

  3. Aflatoxin-B1 Toxicity via DNA Alkylation DNA guanine residue Aflatoxin B1 Aspergillus flavus Fungus in contaminated nuts and grains Aflatoxin B1 epoxide Toxin bound to DNA Inhibition of DNA replication, RNA synthesis, mutagenesis

  4. Glutathione Conjugation with Aflatoxin-B1 Metabolite Allows its Removal From Body Glutathione Aflatoxin B1 epoxide Aflatoxin B1 Glutathione aflatoxin conjugate Detoxification, removal from body

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