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CELL COMMUNICATION

CELL COMMUNICATION. Slide show modified from a PREZI by David Knuffke. KINASE: Protein that “phosphorylates” (adds a phosphate to) another molecule TYROSINE KINASES: Proteins that form dimers. Tyrosine amino acid residues are active in transfer of phosphates to relay proteins

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CELL COMMUNICATION

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  1. CELL COMMUNICATION Slide show modified from a PREZI by David Knuffke

  2. KINASE: Protein that “phosphorylates” (adds a phosphate to) another molecule • TYROSINE KINASES: Proteins that form dimers. Tyrosine amino acid residues are active in transfer of phosphates to relay proteins • Remain ACTIVE as long as LIGAND is attached

  3. Incoming IONS trigger the response

  4. Calcium ions are another common 2nd messenger

  5. Internal signalling molecules released due to external “girst” signals. Trigger sub-response pathways

  6. YOUTUBE Video

  7. The L

  8. AMPLIFICATIONMORE FROM LESS Cells amplify the message

  9. COMPLICATIONA “Branching Network” Simplicity leads to COMPLEXITY • S

  10. MORE EXAMPLESWhy cells communicate? • Wound healing • QUORUM SENSING in bacteria communication among microbes that triggers group response when population reaches certain density • APOPTOSIS-Programmed cell death • Yeast mating

  11. QUORUM SENSING

  12. APOPTOSIS“Cell suicide” Why are “Death proteins“ present in inactive form?

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