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A challenging case of eosinophilia, the era of personalized medicine has the key

A challenging case of eosinophilia, the era of personalized medicine has the key. Rame Khasawneh , MD, FABMG King Hussein Medical Center Jordan Royal Medical Services. Outline. Case presentation Eosinophil Causes of eosinophilia

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A challenging case of eosinophilia, the era of personalized medicine has the key

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  1. A challenging case of eosinophilia, the era of personalized medicine has the key RameKhasawneh, MD, FABMG King Hussein Medical Center Jordan Royal Medical Services

  2. Outline • Case presentation • Eosinophil • Causes of eosinophilia • Myeloid neoplasms with eosinophilia and abnormalities of PDGFRA • Conclusion remarks

  3. The Case • 28 year old lady • Referred from Prince Rashid Hospital • -Recurrent oral ulcerations -Recurrent genital ulcerations -Uveitis

  4. Physical examination • Pale • Normotensive Temp 37.5C • H&N :Normal • Chest :clear • Heart: tachycardia N S1,S2 • Abdomen : splenomegaly • MSK :RT elbow and left Knee effusion

  5. Lab Data CBC: WBC 44,000 PCV 21 PLAT 140,000 Blood film: Normochromic Normocytic anemia Eosinophilia

  6. Diagnosis Behcet syndrome with uveitis and arthropathy With eosinophilia ??

  7. Eosinophil • Hoffbrand, Victor, Paul Moss. Essential Haematology, 2nd Edition. John Wiley & Sons (STMS), 2/25/2011.

  8. Causes of eosinophilia Jaffe, Hematopathology . 1st edition, 2011

  9. Eosinophilia Work UP Jaffe, Hematopathology . 1st edition, 2011

  10. Eosinophilia Urgency Jaffe, Hematopathology . 1st edition, 2011

  11. Our Case Jaffe, Hematopathology . 1st edition, 2011

  12. Myeloid neoplasmswith eosinophilia and abnormalities ofPDGFRA • WHO classification, 2008.

  13. Diagnosis • Leukemia (2004) 18, 734–742.

  14. What is the deal

  15. Take home messages • There are several causes of eosinophilia where clinicopathological correlation is of paramount importance to elucidate the etiology. • Eosinophilia raises red flag in certain cases • Personalized medicine could stratify and flip over the prognosis through genetic studies.

  16. References • 1. Leukemia. 2004 Apr;18(4):734-42 • 2. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, Fourth Edition 2008 • 3. Hematol Oncol. 2010 Jun;28(2):93-7. doi: 10.1002/hon.919 • 4. Arch Pathol Lab Med. 2013 Feb;137(2):259-69. doi: 10.5858/arpa.2011-0597-RA

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