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Genetic Cancer Risk Assessment: in the Era of Personalized Medicine

Genetic Cancer Risk Assessment: in the Era of Personalized Medicine. Yuan Wenqing Lab of Genetics Mar. 24, 2014. Outline. Current State of the Art and Evolving Models in the Practice of GCRA. Barriers to Access and Effectiveness of GCRA. The Multidisciplinary Model of GCRA.

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Genetic Cancer Risk Assessment: in the Era of Personalized Medicine

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  1. Genetic Cancer Risk Assessment: in the Era of Personalized Medicine Yuan Wenqing Lab of Genetics Mar. 24, 2014

  2. Outline Current State of the Art and Evolving Models in the Practice of GCRA Barriers to Access and Effectiveness of GCRA The Multidisciplinary Model of GCRA

  3. Current State of GCRA • Genetic Cancer Risk Assessment (GCRA): GCRA is an interdisciplinary medical practice that employs a growing arsenal of genetic and genomic tools to identify individuals and families with inherited cancer risk.

  4. Current State of GCRA-Pedigree Drawing Family history is the single most important indicators of single gene hereditary cancer risk for which early recognition and intervention could be lifesaving Genetics in Medicine (2011) 13, 651–657.

  5. Current State of GCRA-Pedigree Drawing Web-based surveys Family History Tools Structured interview Self-administered paper

  6. Current State of GCRA-Tools of GCRA Practice

  7. Current State of GCRA-Tools of GCRA Practice Genet Med. 2009. 11(7): 495-506.

  8. Current State of GCRA-Pedigree Drawing The FHS-7 questionnaire for breast cancer: BMC Cancer. 2009; 9: 283.

  9. Current State of GCRA-Pedigree Drawing The pre-procedural Colorectal Cancer Risk Assessment Tool: Am J Gastroenterol. 2009. 104(6): 1508-18.

  10. Current State of GCRA-Pedigree Drawing The Breast Cancer Genetics Referral Screening Tool: http://www. brcagenscreen. org/

  11. Current State of GCRA-Pedigree Drawing

  12. Current State of GCRA-Pedigree Drawing The family HealthLink J Clin Oncol. 2002; 20(2):528-37.

  13. Current State of GCRA-Pedigree Drawing Web-based surveys Family History Tools Structured interview Self-administered paper

  14. Current State of GCRA-Pedigree Drawing Pedigree Drawing and Database Programs: • Progeny Software • Cyrillic • CancerGene: BRCAPRO, MMRpro, PancPRO, MelaPRO • Hughes riskApps system • My Family Health Portrait pedigree program

  15. Current State of GCRA-Differential Diagnosis • Clinical syndromes • Pathology report review

  16. Current State of GCRA-Mutation Probability Estimate

  17. Current State of GCRA-Mutation Probability Estimate

  18. Current State of GCRA-Risk Prediction

  19. Barriers to Access and Effectiveness of GCRA • Systemic Barriers • Patient-Related Barries

  20. The Complexity of Genetic and Genomic Test Information

  21. TheMultidisciplinary Model of GCRA • Multidisciplinary team for GCRA:

  22. TheMultidisciplinary Model of GCRA

  23. TheMultidisciplinary Model of GCRA

  24. Riding on the crest! Thank you!

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