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Experimental Annotations in ROC

Experimental Annotations in ROC. Russ Altman, Alain Laederach Based on our experiences with RiboWeb and our participation in a Program Project Grant. Chalk Talk. Structural Information. PDB Evidence for Structural Motifs Base Pairs, Long range interactions etc. Experiments

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Experimental Annotations in ROC

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  1. Experimental Annotations in ROC Russ Altman, Alain Laederach Based on our experiences with RiboWeb and our participation in a Program Project Grant

  2. Chalk Talk

  3. Structural Information • PDB • Evidence for Structural Motifs • Base Pairs, Long range interactions etc. • Experiments • Many Biochemists getting more or less accurate structural evidence as well • DMS Footprinting, Hydroxyl Radical Footprinting • Tethered BABE probes, FRET, NMR, EPR • Even computational folks predict structure • Phylogenetic co-variance analysis • M-Fold

  4. A possible hierarchy

  5. Why is this useful? • We can populate instances from PDB • We can also populate from experiments • Biochemical • Computational • For structure prediction: • Make PDB from ensemble of biochemical data

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