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Erythropoietin protects against diabetes through direct effects on pancreatic beta cells

Erythropoietin protects against diabetes through direct effects on pancreatic beta cells Choi et al. J Exp Med. 2010;207:2831-2842. b- cell. EPO. EPO-R. b- cell. EPO. EPO-R. STZ +/- EPO. Glycemia. STZ Control STZ+EPO. time. b- cell. EPO. EPO-R. STZ 2 weeks. STZ +/- EPO.

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Erythropoietin protects against diabetes through direct effects on pancreatic beta cells

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  1. Erythropoietin protects against diabetes through direct effects on pancreatic beta cells Choi et al. J Exp Med. 2010;207:2831-2842

  2. b-cell EPO EPO-R

  3. b-cell EPO EPO-R STZ +/- EPO Glycemia STZ Control STZ+EPO time

  4. b-cell EPO EPO-R STZ 2 weeks STZ +/- EPO T1 Diabetes EPO Glycemia α-cell β-cell STZ Control STZ+EPO Increased size β-cell proliferation β-cell apoptosis  Reversion of diabetes time

  5. b-cell EPO EPO-R STZ 2 weeks STZ +/- EPO db/db mice T1 Diabetes EPO Glycemia α-cell T2 Diabetes EPO β-cell STZ Control STZ+EPO Increased size β-cell proliferation β-cell apoptosis  Reversion of diabetes Increased size β-cell proliferation β-cell apoptosis  Reversion of diabetes time

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