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DNA Deoxyribonucleic acid. Deoxyribonucleic Acid (DNA) -the ___________________ of all cellular organisms and most viruses -the molecule which is used to encode genetic information for all life on Earth. Within cells, DNA is organized into structures called ______________
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Deoxyribonucleic Acid (DNA) -the ___________________ of all cellular organisms and most viruses -the molecule which is used to encode genetic information for all life on Earth
Within cells, DNA is organized into structures called ______________ Eukaryotes (animals, plants, fungi, and protists) store their DNA inside the cell’s ___________ While in prokaryotes (bacteria and archaea) it is found in the cell's _______________
In a normal ___________ cell, DNA is contained in the nucleus • The DNA coils around itself and proteins to form chromosomes • There are normally ____________ of chromosomes in a human cell
Chromosomes 22 pairs of chromosomes are ______________ (body cells) The 23rd chromosome pair determines the sex of individual and is composed of either: two X chromosomes (XX: ___________) or an X and Y chromosome (XY: _______)
Main Structure • A _______________ which consists of 3 parts: • Sugar = Deoxyribose • Phosphate • Nitrogenous Bases (4) “Double Helix” shape
Double Helix Model X-ray of DNA “Twisted “ladder”
4 Nitrogenous Bases • ___=Adenine • ___=Thymine • ___=Guanine • ___=Cytosine Pairs: A+T = always G+C = always A + T G + C
What are the matching BASE PAIRS? T A C T G C ___________ Now try this…. A C T G C A G T C A ____________________ You’ve got it!
Who Discovered DNA? • In 1953, James WATSON and Francis CRICK established the _________________ structure • Used work from Rosalind Franklin and Maurice Wilkins in 1952 • Rosalind Franklin died in 1958 and did not get credit for her work
DNA Replication Part 2 Notes • Replication=When DNA makes a______of itself • Why does DNA need to copy? • Cells divide for an organism to grow and reproduce • DNA gives_______________to cells • DNA replicates right before a cell divides • This is known as MITOSIS (remember?)
Steps of DNA Replication 1. DNA double helix must “unzip” with the help of an enzyme called DNA__________ 2. New bases (A,T,G,C) are added 3. Two new strands are created, each with_______of the original strand
What is RNA? • RNA=ribonucleic acid • DNA remains in the nucleus, but in order for it to get its instructions translated into proteins, it has to use RNA • RNA is similar to DNA except: • __________stranded • __________instead of Thymine • _________instead of deoxyribose
Transcription • -mRNA (________________ RNA) - takes message from DNA in the nucleus to the ribosomes • DNA- GCGTATG • RNA- CGCAUAC
Transcription • RNA is made from DNA in the nucleus • RNA moves to ribosomes to make_________________ Transcription Video End of Part 2 Notes
Part 3 Notes Translation • -_____________are made from the message on the RNA -_________________ is translated from mRNA triplets (3 base pairs called__________)into amino acids -Example:UGG codonis tryptophan (the amino acid found in turkey) *These amino acids are then made into proteins*
What is a Codon? • _____________________that code for a specific amino acid • 64 codons (ex: GCU, GGU) • 20 amino acids (ex: Alanine, Glycine)
Translation & Protein Synthesis -tRNA (___________ RNA) - carries amino acids from cytoplasm to ribosome -_______________ - a region of tRNA consisting of 3 bases that are complementary to the codon of mRNA Example: -mRNA codon UGC =tRNA codon ACG Steps: codons proteins amino acids
Protein Synthesis:The Big Picture Animation: Protein Synthesis
Function of DNA • ____________of genetic information • Transmission of genetic information • Allows for genetic _____________
DNA Damage • DNA damage can result from spontaneous alteration of the DNA molecule or from the interaction of numerous ____________and____________agents with the structural DNA molecule • Ex’s: UV radiation, carcinogens, etc.
DNA Damage • Spontaneous _________ can occur during normal cellular processes, such as, DNA replication, DNA repair, or gene rearrangement, or through chemical alterations of the DNA molecule itself • The various forms of spontaneous and induced DNA damage can give rise to different types of _______________ • Why are mutations important?
DNA uses in Technology • Genetic engineering - alters the genetics makeup of an organism; not natural! Ex: GMOs • Forensic science - solving crimes using DNA • _______________ - Human Genome Project • DNA nanotechnology - create electronic structures Biotoxins present in peanut leaves (bottom image) protect it from extensive damage caused by European corn borer larvae (top image)