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PhD Research Project

PhD Research Project. Non-linear determination of planning treatment volume growth margins in radiotherapy. Researcher: Bon Mzenda Supervisors: David Brown, Alex Gegov & Mir Hosseini-Ashrafi. Purpose.

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PhD Research Project

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  1. PhD Research Project Non-linear determination of planning treatment volume growth margins in radiotherapy Researcher: Bon Mzenda Supervisors: David Brown, Alex Gegov & Mir Hosseini-Ashrafi

  2. Purpose Use of novel computational techniques to derive margins for use in cancer treatment with external beam radiotherapy, based on the radiobiological effects of organ motion, patient set-up variations and delineation errors.

  3. Fuzzy logic-based margin derivation • Why fuzzy logic? • Parameters for tumour control (TCP), damage to healthy tissues (NTCP), organ motion, set-up errors and required margin cannot be easily combined using mathematical methods • FL offers linguistic rules and membership functions that allow linking of these variables

  4. Fuzzy model results • Good agreement between fuzzy results and current • margin formulations • Advantage of FL is that it shows acceptable • maximum usable limit of margin sizes

  5. Fuzzy network • Under investigation to improve transparency of initial fuzzy system • Results also show acceptable margins for clinical use

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