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b -Cell Function Preservation After 3.5 Years of Intensive Diabetes Therapy

Featured Article :. b -Cell Function Preservation After 3.5 Years of Intensive Diabetes Therapy. Lindsay B. Harrison, M.D., Beverley Adams-Huet, M.S., Philip Raskin, M.D., Ildiko Lingvay, M.D., M.P.H., M.S.C.S. Diabetes Care Volume 35: 1406-1412 July, 2012. Study Objectives.

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b -Cell Function Preservation After 3.5 Years of Intensive Diabetes Therapy

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  1. Featured Article: b-Cell Function Preservation After 3.5 Years of Intensive Diabetes Therapy Lindsay B. Harrison, M.D., Beverley Adams-Huet, M.S., Philip Raskin, M.D., Ildiko Lingvay, M.D., M.P.H., M.S.C.S. Diabetes Care Volume 35: 1406-1412 July, 2012

  2. Study Objectives • To assess b-cell function preservation after 3.5 years of intensive therapy with: • Insulin plus metformin (INS group) • vs. • Triple oral therapy (TOT group) with metformin, glyburide, and pioglitazone Harrison L et al. Diabetes Care 2012;35:1406-1412

  3. Study Design & Methods • Randomized trial of 58 patients with treatment-naïve newly diagnosed type 2 diabetes • All patients treated with insulin and metformin for a 3-month lead-in period • Followed by random assignment to the INS or TOT group • b-Cell function assessed using a mixed-meal challenge test at randomization and 6, 12, 18, 30, and 42 months • Analyses were intention to treat and performed with repeated-measures models Harrison L et al. Diabetes Care 2012;35:1406-1412

  4. Harrison L et al. Diabetes Care 2012;35:1406-1412

  5. Harrison L et al. Diabetes Care 2012;35:1406-1412

  6. Harrison L et al. Diabetes Care 2012;35:1406-1412

  7. Harrison L et al. Diabetes Care 2012;35:1406-1412

  8. Conclusions • b-Cell function can be preserved for at least 3.5 years with early and intensive therapy for type 2 diabetes with either insulin plus metformin or triple oral therapy after an initial 3-month insulin-based treatment period Harrison L et al. Diabetes Care 2012;35:1406-1412

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