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Sintocheck The ideal binder for MYCOTOXIN

Sintocheck The ideal binder for MYCOTOXIN. DEFINITION. Mycotoxins are metabolites of molds growing on feedstuffs ( Aspergillus, Fusarium, Penicillum) .They are spread everywhere and are able to bring about poisoning in the animals that assume contaminated feed.

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Sintocheck The ideal binder for MYCOTOXIN

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  1. Sintocheck The ideal binder for MYCOTOXIN

  2. DEFINITION Mycotoxins are metabolites of molds growing on feedstuffs (Aspergillus, Fusarium, Penicillum).They are spread everywhere and are able to bring about poisoning in the animals that assume contaminated feed Many mycotoxins can contaminate crops before harvest under certain circumstances of humidity and temperature .  FIELD MYCOTOXINS During the time between harvesting and drying , and in storage  STOCK MYCOTOXINS

  3. THE MAIN MYCOTOXINS ASPERGILLUS Flavus, ParasiticusAFLATOXINS (B1, B2, G1, G2) OchraceusOCHRATOXIN FUSARIUM Graminearum, MoniliformeZEARALENONE, FUMONISIN • Sporotrichoides(DAS, T2,DON) PENICILLUM Cyclopium PENICILLIC ACID CitrinumCITRININ RubrumRUBRATOXIN ViridicatumOCHRATOXIN

  4. TOXIC EFFECT OF THE MYCOTOXINS • Common is the presence of various mycotoxins, even though present in small amounts,they add their effects,determining a synergistic effect.. • …. are more dangerous at low levels of different mycotoxins than high levels of single mycotoxin • Mycotoxins are resistant to all technological treatments.

  5. Undesirable substance Products intended for animal feed Maximum content in ppm relative to a feedingstuff with a moisture content of 12 % AFLATOXIN B1 All feed materials Complete feedingstuffs for cattle,sheep and goats with the exception of: -complete feedingstuffs for dairy animals -complete feedingstuffs for calves and lambs Complete feedingstuffs for pigs and poultry (except young animals) Other complete feedingstuffs Complementary feedingstuffs for cattle, sheep and goats (except complementary feedingstuffs for dairy animals, calves and lambs) Complementary feedingstuffs for pigs and poultry (except young animals) Other complementary feedingstuffs 0,02 0,02 0,005 0,01 0,02 0,01 0,02 0,02 0,005 MYCOTOXIN LEGISLATION Directive 2002/32/EC on undesirable substances in animal feed (2006/02/24) • (with the new normative may not be mixed for dilution!!)

  6. Undesirable substance Products intended for animal feed Maximum content in ppm relative to a feedingstuff with a moisture content of 12 % OCHRATOXIN A Feed materials -cereals and cereal products Complementary and complete feedingstuffs -complementary and complete feedingstuffs for pigs -complementary and complete feedingstuffs for poultry Feed materials -maize and maize products Complementary and complete feedingstuffs for:: -pigs, horses , rabbits and pet animals -fish -poultry, calves (< 4 months), lambs and kids -adult ruminants (> 4 months) and minki 0,25 0,05 0,1 60 5 10 20 50 MYCOTOXIN LEGISLATION COMMISSION RECOMMENDATION of 17 August 2006 FUMONISINE B1 + B2 FUMONISIN B1+B2

  7. Undesirable substance Products intended for animal feed Maximum content in ppm relative to a feedingstuff with a moisture content of 12 % DEOXYNIVALENOL Feed materials -cereals and cereal products with the exception of maize by-products - maize by-products Complementary and complete feedingstuffs with the exception of: -complementary and complete feedingstuffs for pigs -complementary and complete feedingstuffs for calves (< 4 months), lambsand,kids Feed materials -cereals and cereal products with the exception of maize by-products - maize by-products Complementary and complete feedingstuffs -complementary and complete feedingstuffs for piglets and gilts (young sows) -complementary and complete feedingstuffs for sows and fattening pigs -complementary and complete feedingstuffs for calves, dairy cattle, sheep and goats 8 12 5 0,9 2 2 3 0,1 0,25 0,5 MYCOTOXIN LEGISLATION COMMISSION RECOMMENDATION of 17 August 2006 ZEARALENONE

  8. a kidney trouble Swine nephropaty Vulvovaginitis Prolepsis Embryo mortality Pulmunary Oedema Oral Irritation Liver toxicosis Feed refusal vomiting Intestinal haemorrhage EFFECTS ON SWINE

  9. MYCOTOXIN SYMPTOM TOXIC LIMIT ATTENTION LIMIT AFLATOXIN Liver 1000 ppb 50 ppb TRICOTECENI (T2, DAS, DON) Feed refusal, mucous membrane damage(max mouth) T2,DAS: 3000 ppb DON: 5000 ppb 500 ppb 500 ppb OCHRATOXIN A Protein metabolism, kidneys 1000 ppb 200 ppb FUMONISIN Pulmunary oedema 50000 ppb 10000 ppb ZEARALENONE Estogenic syndrome, reproduction 1000 ppb 100 ppb TOXIC MYCOTOXINS ON SWINE

  10. EFFECTS ON SWINE 500-1000 ppb of Fumonisina ( reproduction and respiratory problems) • Increase incidence of :PRRS, APP; CRV • Pulmunary oedema • Unexpected death • Less immune activity • Increase of E.Coli in the intestinal tract 25-100 ppb of Zearalenone (less fertility) • Less heat during 5 days after weaning • More anaoestrus • Less pigglets live births more abortion; litters less uniform • Rectal and uterus prolapsis

  11. EFFECTS ON SWINE 100-500 ppb Tricoteceni: A: T-2 e DAS; B: DON ( digestion problems ) • Anorexia • Vomiting (12 ppm) • Immunodepression • Delayed growth • Skin and mucous necrosis DAS: Deacetoxiscirpenolo; DON: Deossivalenolo 50- 1000 ppb AFLATOXIN (hepatic problem) • Anorexia • Unexpected death (1000 ppb) • Hepatic damage (necrosy, icterus, lipidosy, hemorrages) • Delayed growth • Immunodepression

  12. mucous membrane Sistema emopoietico ed organi linfoidi kidneys Reproductive organ Bood- vessels arti teratogenicità EFFECTS ON POULTRY

  13. MYCOTOXIN SYMPTOM TOXIC LIMIT ATTENTION LIMIT AFLATOXIN Liver 1000 ppb 50 ppb TRICOTECENI (T2,Das, DON) Mouth, protein metabolism ionofor antibiotic T2, DAS:2000 ppb DON: 10000 ppb 400 ppb 1000 ppb OCHRATOXIN A Protein synthesis, bigger kidneys, increased of fecal moisture 2000 ppb 100 ppb FUMONISIN Nervous system 50000 ppb 10000 ppb ZEARALENONE Reproduction,osseous system 100000 ppb 2000 ppb TOXIC MYCOTOXINS ON POULTRY

  14. EFFECTS ON POULTRY • Immunodepression • Less answer to vaccines • Increase cost of therapy • More mortality • Less yield TOXIC LIMIT • Aflatoxin: 1000 pbb • T-2, DAS: 2000 ppb • DON: 1000 ppm • Ochratoxin A: 2000 ppb Necrosis

  15. Vulvovaginitis Prolepsis Embryo mortality Gastro enteritis Intestinal haemorrhage Immunodepression Cystic ovarian Feed refusal vomiting Milk contamination Decline in milk production Increase in somatic cells EFFECTS ON RUMINANTS

  16. EFFECTS ON RUMINANTS ZEARALENONE/DON • Cistic ovarian • Miscarriages • More anaoestrus • Less heat TRICOTECENI AND OTHER MYCOTOXIN • Immunodepression • Less ingestion • Decline in milk production AFLATOXIN B1 AND M1:they are a problem for the health of the consumer Legislative decree n° 149 of 10 May 2004

  17. POSSIBLE STRATEGIES IN ORDER TO PREVENT AND TO MANAGE THE MYCOTOXIN PROBLEMS 1 Establish an adequate quality control of feedstuffs2 Use of mould inhibitor during storage3 Use mycotoxins binder

  18. ANTIMOULD ADDITIVES • They do not have to be considered the exclusive method of control • Combinations of organic acids (propyonic, sorbic, benzoic andacetic) or salts of organic acids (calcium propionate and potasiumsorbate) • They must be distributed uniform on all the feed BUT ABOVE ALL They do not have effect on the mycotoxins produced on the field

  19. ADDITIVES ADSORBENT MYCOTOXINS Sintocheck Natural Mycotoxin Binder Composition: Hydrated Sodium Calcium Aluminosilicate (HSCAS) New concept: BY USING A WELL BALANCED,COMBINATION OF DIFFERENT HSCAS THAT AREACTIVED BY A HEAT DRYING PROCESS , WE WELL OBTAIN A SYNERGIC EFFECT,INCREASING THE CAPACITY AND SPECTRUM OF MYCOTOXIN BINDER.

  20. WHY CLAYS ARE DIFFERENT? HOW TO COMPARE THEM? CEC: Cation Exchange Capacity (MEQ) < 19 MEQ is considered a saturation point,which makes the clay have a neutral charge,it's adsorption capacity is minimal >60 MEQ is considered a high CEC,which can interfere in the adsorption of nutrients,especially minerals. Sintocheck (mixture of illites and chlorites) 20-60 MEQ

  21. DIPOLAR – POLAR Dipolar clays have a wide spectrum of adsorption of mycotoxins. Polar clays (such as Bentionites) have a negative charge and can only adsorb mycotoxins with a strong positive charge WHY CLAYS ARE DIFFERENT? HOW TO COMPARE THEM? EXPANDABLE: Hight cation exchange,more than 60MEQ. Absorb water. Absorb nutrients.NON EXPANDABLE: Lower than 60 MEQ cation exchange capacity. Very small to almost no water absorption. Very little to no absorption of nutrients. Sintocheck is not expandable Sintocheck is dipolar

  22. WHY CLAYS ARE DIFFERENT? HOW TO COMPARE THEM? PORE SIZE AND SURFACE AREA Bentonite = Hight CEC = Smaller surface area = less binding sites Bentonite = Pore size of 1,5 to 1,8 A Illites and chlorites (silicates) = Smaller CEC = Larger surface activity = more binding sites. Illites and chlorites (silicates) = Larger pore size, in range of 2,5 A PARTICLE SIZE The size of particle is very critical: • less than 300 mesh reduces the surface area • - the best size is between 300 and 400 mesh -at 400 mesh or higher ,particles are too small and could represent hazardous problems to workes. Sintocheck has a particle size , which is the best for a superior adsorbent

  23. WHY CLAYS ARE DIFFERENT? HOW TO COMPARE THEM? PH There is an interrelationship between the pH of the clay and where the binding is performed in the GI tract of the animal. Clays with an acid pH tend to work better in the large intestine. Clays with an alkaline pH perform their binding in the lower intestine. Many scientists and nutritionists believe it is better for a clay to work in the lower intestine. SINTOCHECK HAS A PH OF 7,8 TO 8, THEREFORE IT PERFORMS BINDING IN THE LOWER INTESTINE

  24. WHY CLAYS ARE DIFFERENT? HOW TO COMPARE THEM? TEMPERATURE WHICH THE CLAYS ARE SUBMITTED TO DURING PROCESSING Temperature may have an effect on the cation exchange due to solubility and temperature reationship. Many clays are extracted from the ground ,then ground into finer particles with no heat being applied for drying. Drying clays at normal temperatures of 200 to 300 F°(95-150°C) can make the clay more active and have a better cation interchange. If excess temperature is used in drying,for example,900 F°(480°C),the components crystallize or fragment,rendering the clay ineffective as a single component or as a unit for mycotoxin adsorbtion. SINTOCHECK is dried at temperature of 100 and 105 °C which is the range of temperature which can make the clay more active and have better cationic exchange,therefore a must better binder.

  25. SINTOCHECK It is different because… • Hydrated Sodium Calcium Aluminosilicate (HSCAS) natural • Big binding capacity and large spectrum of mycotoxin binder • Irriversible bond with mycotoxins • The small particle size allows an optimal homogenization with the other feed ingredients contributing to solve also the problems of fluidity and caking.

  26. BINDING CAPACITY OF SINTOCHECK SINTOCHECKis tested using 5ppm mycotoxin at inclusion level of 2,5 Kg/TON 99% Aflatoxin M1 97% Citrinin 95% Aflatoxin B1 94% T2 84% Vomitoxin 84% Don 72% Fumonisin B1 72% Ochratoxin A 43% Zearalenone M1 CIT B1 T2 VOM DO F.B1 0CR ZEA

  27. A CONCEPT OF HOW SINTOCHECK WORKS • MAGNETIC ATTRACTION: A difference in electrical charge between Sintocheck and mycotoxins. Sintocheck works like a magnet mycotoxin 2. PARTICLE SIZE: The particle size of Sintocheck provides a larger surface area that maximizes the binding of mycotoxins. OTHER PRODUCT Sintocheck MYCOTOXIN MYCOTOXIN

  28. A CONCEPT OF HOW SINTOCHECK WORKS 3.PORE VOLUME: SINTOCHECKhas an ideal pore volume to bind a large percentage of mycotoxins. Using SINTOCHECK is like having a number of magnets in one. SINTOCHECK with bound mycotoxins MICOTOXIN MICRO-BOND MICOTOXIN MICOTOXIN BINDING MYCOTOXINS CAUSES A LARGER COMBINED PARTICLE OR MOLECULAR SIZE WHICH IS NOT ADSORBED BY THE DIGESTIVE TRACT. IT IS PASSED IN THE FECES,CAUSING NO HARM TO THE ANIMAL'S PERFORMANCE.

  29. SINTOCHECK SINTOCHECK does not affect,nor is affected by other ingredients such as: • antibiotics/medicinal • riboflavin • vitamin A- zinc - manganese • phosphorus Dosage: 2,5 Kg/ton

  30. Pigs, poultry,fishes, horses, pets Per ton of feed Ruminants Prevention of risk 1,0-1,5 Kg dairy cows 60 g/head /day Sospect of mycotoxin 1,5-2,0 Kg beef cattle 50 g/head /da Presence of mycotoxin 2,0-2,5 Kg SINTOCHECK

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