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VGCC

NCE. mM [Ca]. NMDA, AMPA rec. nAChR. CNG. VR/temp rec. VDAC. Stretch receptor. TRP. mM [Ca]. SOC. IP3R. SERCA. 100 nM [Ca]. ROC. VGCC. mM [Ca]. PMCA. RyR. SERCA. Sarcoplasmic Reticulum (SR) / T Tubule System. Twitch. Summation. Tetanus. Role of Ca ++ in contraction.

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VGCC

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  1. NCE mM [Ca] NMDA, AMPA rec nAChR CNG VR/temp rec VDAC Stretch receptor TRP mM [Ca] SOC IP3R SERCA 100 nM [Ca] ROC VGCC mM [Ca] PMCA RyR SERCA

  2. Sarcoplasmic Reticulum (SR) / T Tubule System

  3. Twitch

  4. Summation

  5. Tetanus

  6. Role of Ca++ in contraction

  7. vertebrate skeletal muscle contraction

  8. Excitation-contraction coupling Ryanodine receptors

  9. RyR

  10. 500 1000 NH2 PP1 MH/CCD 1500 2000 DHPR/RyR1 PP2A FKBP MH/CCD 2500 Ca-Activation 3000 P 3500 mAKAP RII-PKA PKA/CamKII PO4 site Calmodulin Ca-Inactivation 4000 5000 4500 CO2H Ryanodine Cytosol RyR2 SR Membrane GIG M1 M2 M3 M4 Lumen MH/CCD

  11. Voltage-gated ion channels

  12. Regulation of EC coupling by adrenergic signaling -- “fight or flight”

  13. RyR2 macromolecular complex

  14. RyR macromolecular complexes are held together by leucine/isoleucine zippers

  15. RyR2/calcium release channel phosphorylated by addition of cAMP alone

  16. PKA phosphorylation activates RyR2 and induces subconductance states

  17. RyR2 open probability Iso CHF ECC gain Ca transient contractility [Ca] DADs - SCD Cytosolic [Ca] Time

  18. Excitation-secretion coupling Inositol 1,4,5-trisphosphate receptors

  19. IP3 signaling

  20. Stable transfectant Jurkat T cells do not express IP3R1 IP3R1

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