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The Brain. Some interesting brain facts. Brain weighs 3 lbs However, it is completely immersed in liquid (cerebrospinal fluid) and, as a result, its effective weight is 3 ounces . Brain uses 20% of the body’s blood, 20% of its oxygen, and 70% of its glucose. 80% of the human brain is cortex
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Some interesting brain facts • Brain weighs 3 lbs • However, it is completely immersed in liquid (cerebrospinal fluid) and, as a result, its effective weight is 3 ounces. • Brain uses 20% of the body’s blood, 20% of its oxygen, and 70% of its glucose. • 80% of the human brain is cortex • Cortex is virtually absent in fish, reptiles, and birds • 1/3 of the cortex is visible • Cortex is 1/8” thick and, if spread out flat, is about the size of 1 sheet of newspaper (4 pages of a textbook) • Localization of function vs. equipotentiality (mass action) • Broca’s area is in the frontal lobe; when destroyed, patient cannot produce language, but can comprehend language; Broca’s aphasia • Wernicke’s area is in the temporal lobe; when destroyed patient cannot comprehend language, but can produce language; Wernicke’s aphasia
Direction in the brain • We are symmetrical around our midline: we have a left arm and a right arm, a left ear and a right ear, etc. • Medial: close to the midline • Lateral: farther from the midline; closer to the “side” of the head
Some brain structure terminology • Sulcus (pl. sulci): any of the shallow grooves separating the convolutions (bumps, ridges) on the surface of the brain • Fissure: a very deep groove that, typically, separates major cortical structures • Gyrus (pl. gyri): a convolution (bump, ridge) on the brain surface • Commisures: a fiber bundle that interconnects corresponding regions on each side of the brain • White matter (mylinated axons) and gray matter (cell bodies) • Cortical structures are specialized parts of the cortex. • Everything else under the cortex, but above the brainstem, is referred to as a subcortical structure.
Some brain organization terminology • Hemispheres • The two relatively symmetrical halves of the brain; one on the left and one on the right • Contralaterality • The left hemisphere receives sensory input from, and sends motor messages to, the right side of the body; vice versa for the right hemisphere • Cerebral lateralization (hemispheric specialization) • Instances in which one of the hemispheres is more responsible for a particular cognitive function than the other hemisphere • Left hemisphere specialized for language and analytical thought • Right hemisphere specialized for visual-spatial tasks, music, face recognition, and emotional states • Cerebral dominance • In 90% of human beings, the left hemisphere is specialized for language and these individuals are right-handed; thus, the left hemisphere is said to be the dominant hemisphere
Brainstem • Medulla • Vital involuntary functions • Pons • Sleep and arousal • Reticular formation • Sleep, arousal, attention • Cerebellum • Motor coordination • Also involved in planning, memory, language, and emotion
Limbic System I: Emotion and motivation • Hypothalamus • Regulates • Glands • Autonomic system • Eating • Drinking • Sleeping • Sexual activity • Plays a role in emotion • Amygdala • Forms learned associations between objects and emotion, especially fear
Limbic system II: Cognitive functions • Thalamus • Sensory relay station • Hippocampus • Formation of new memories • Basal ganglia • Putamen, globus pallidus, caudate nucleus • Motor behavior • Habit learning
Neglect Syndrome (Hemineglect) • A patient with a stroke in the right hemisphere was asked to copy the model drawings • Typical of neglect syndromes, the left side of the model is almost completely ignored
The Nervous System
The Autonomic Nervous System “Fight or Flight” Restore Calm
The Endocrine System • Endocrine system: Ductless glands that regulate growth, reproduction, metabolism, mood, and some behavior • Hormones: chemical messengers secreted into the bloodstream • Chain of command • Hypothalamus commands the pituitary, which in turn releases hormones that command the other glands to release their hormones
Brain Change • Plasticity • A property of the brain that allows it to change as a result of experience, drugs, or injury • Chemical signals guide growing connections. • Experience fine-tunes neural connections. • Critical periods • Rats in special environments have heavier brains with more synaptic connections • Change in the strength of connections underlies learning • Hebbian learning: “fire together, wire together” • Neurogenesis: production of new brain cells in the adult brain • Brain reorganization in response to overuse or underuse • Devoting more cortex to information that is pertinent for tasks at hand • Blind people who read Braille have much larger areas of cortex devoted to receiving input from index fingers than do sighted individuals • Brain reorganization in response to brain injury • Much more likely to occur in the young • Treatment for brain injury or disease • Neural grafting, using stem cells