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Disorders of the Muscular System

Disorders of the Muscular System. Development Defects. muscular dystrophy degeneration and atrophy of muscles fibers enlarge due to fat and connective tissue deposits Duchenne’s MD abnormal gene located on X chromosome affects 1 in 3000 boys usually diagnoses around age 3

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Disorders of the Muscular System

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  1. Disorders of the Muscular System

  2. Development Defects • muscular dystrophy • degeneration and atrophy of muscles • fibers enlarge due to fat and connective tissue deposits • Duchenne’s MD • abnormal gene located on X chromosome • affects 1 in 3000 boys • usually diagnoses around age 3 • causes weakness of muscles, usually pelvic girdle first • Myotonic MD • caused by a genetic mutation • most common form of MD in adults • myotonia - a stiffening of the muscles after use

  3. Muscular Disorders • myasthenia gravis • comes on during adulthood • usually women under 40 • due to shortage of acetylcholine receptors in neuromuscular junction • possibly autoimmune disease • drooping of upper eyelids, difficulty swallowing and breathing, generalized muscle weakness • leads to respiratory failure and death

  4. Muscular Disorders • myositis • inflammation of skeletal muscles • caused by injury, infection or autoimmune disease • polymyositis • muscle weakness, usually in the muscles closest to the trunk of your body. • dermatomyositis • skin rash with muscle weakness

  5. Muscular Disorders • Amyotrophic lateral sclerosis (ALS) • Lou Gehrig's disease • attacks neurons in brain and spinal cord. • early symptoms • trouble walking or running • trouble writing • speech problems • Eventually, lose your strength and cannot move. • causes respiratory failure • usually strikes between age 40 and 60 • more common in men • unknown cause • can run in families • no cure • Medications can relieve symptoms and/or prolong survival.

  6. Muscular Disorders • myositisossificans --fibrodysplasiaossificans progressive (FOP) • Connective tissue or muscle turns to bone. • rare; usually a result of trauma  http://www.youtube.com/watch?v=tNmpzG3BAcM

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